The long-term outcomes of tobacco control strategies based on the cognitive intervention for smoking cessation in COPD patients

Liu, Si; Li, Meilei; Duan, Wenbing; Peng, Caiqin; Chen, Ping; Wu, Shangjie

doi:10.1016/j.rmed.2020.106155

Cited by 8 publications

(17 citation statements)

References 30 publications

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“…Pulmonary outer membrane fibroblasts, the extracellular matrix, and inflammatory cells are involved in this progress, but the thickening of the middle membrane caused by the excessive proliferation and apoptosis resistance of PASMCs is the most important factor leading to pulmonary vascular remodeling [26][27][28][29][30]. Accordingly, scholars have studied PASMCs by exploring the effect of traditional Chinese medicine [31][32][33][34][35][36], and the roles of molecules related to tumors and other diseases [37][38][39][40], as well as the effect of noncoding RNAs, such as microRNAs and LncRNAs on PASMC phenotypic changes [41][42][43][44][45][46][47][48].…”

Section: Discussionmentioning

confidence: 99%

FUT8-Mediated Core Fucosylation Promotes the Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension

Zhang¹,

Lin²,

Zeng³

et al. 2023

Aging and disease

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Pulmonary arterial hypertension (PAH) is a progressive cardiopulmonary disease with unclearunderlying molecular mechanisms and limited therapeutic options. This study aimed to explore the role of core fucosylation and the only glycosyltransferase FUT8 in PAH. We observed increased core fucosylation in a monocrotaline (MCT)-induced PAH rat model and isolated rat pulmonary artery smooth muscle cells (PASMCs) treated with platelet-derived growth factor-BB (PDGF-BB). We found that 2-fluorofucose (2FF), a drug used to inhibit core fucosylation, improved hemodynamics and pulmonary vascular remodeling in MCT-induced PAH rats. In vitro, 2FF effectively restrains the proliferation, migration, and phenotypic switching of PASMCs and promotes apoptosis. Compared with controls, serum FUT8 concentration in PAH patients and MCT-induced rats was significantly elevated. FUT8 expression appeared increased in the lung tissues of PAH rats, and the colocalization of FUT8 with α-SMA was also observed. SiRNA was used to knockdown FUT8 in PASMCs (siFUT8). After effectively silencing FUT8 expression, phenotypic changes induced in PASMCs by PDGF-BB stimulation were alleviated. FUT8 activated the AKT pathway, while the admission of AKT activator SC79 could partially counteract the negative effect of siFUT8 on the proliferation, apoptotic resistance, and phenotypic switching of PASMCs, which may be involved in the core fucosylation of vascular endothelial growth factor receptor (VEGFR). Our research confirmed the critical role of FUT8 and its mediated core fucosylation in pulmonary vascular remodeling in PAH, providing a potential novel therapeutic target for PAH.

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Section: Discussionmentioning

confidence: 99%

FUT8-Mediated Core Fucosylation Promotes the Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension

Zhang¹,

Lin²,

Zeng³

et al. 2023

Aging and disease

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show abstract

“…Further reading of the full text was re-screened to exclude 58 papers with the same data, outcome indicators that did not match, data that could not be translated into application, and lower quality. Ultimately, we included 11 articles [25][26][27][28][29][30][31][32][33][34][35] in our analysis, consisting of 9 Chinese-language articles [25][26][27][28][29][30][31][32][33] and 2 English-language articles [34][35]. A total of 3830 patients were included, including 1989 in the trial group and 1841 in the control group.…”

Section: Literature Search Outcomesmentioning

confidence: 99%

“…11 RCTs published between 2013 and 2023 were included in the meta-analysis. The studies were based on three different theories, including seven on the timing theory [25][26][27][28][29][30][31], two on the 5A nursing model [32][33], and two on the cognitive-behavioral theory [34][35]. One study on "Theory of Planned Behavior" [36] was not included in the meta-analysis because it was not an RCT.…”

Section: The Basic Characteristics Of Studiesmentioning

confidence: 99%

“…All studies were graded B in quality. Ten studies [25][26][27][28][29][30][32][33][34][35] described the generation of randomized sequences, with seven studies [25-28, 30, 33, 35] using random number tables for grouping, one study [29] using odd-even numbering for grouping, one study [32] grouping according to patient preference, and one study [34] mentioning randomization but not specifying the method used. None of the 11 studies had any dropouts or missing data reports, and the experimental and control groups were comparable in terms of baseline levels before the intervention (P > 0.05).…”

Section: Quality Assessmentmentioning

confidence: 99%

“…Ten studies [25][26][27][28][29][30][31][33][34][35] were evaluated for smoking cessation rates. A heterogeneity test was conducted, resulting in an I 2 = 71% and P < 0.001.…”

Section: Smoking Cessation Ratesmentioning

confidence: 99%

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The effectiveness of theory-based smoking cessation interventions in patients with chronic obstructive pulmonary disease: A meta-analysis

Han

et al. 2023

Preprint

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Background Smoking cessation can effectively reduce the risk of death, alleviate respiratory symptoms, and decrease the frequency of acute exacerbations in patients with chronic obstructive pulmonary disease (COPD). Effective smoking cessation strategies are crucial for the prevention and treatment of COPD. Currently, clinical interventions based on theoretical frameworks are being increasingly used to help patients quit smoking and have shown promising results. However, theory-guided smoking cessation interventions have not been systematically evaluated or meta-analyzed for their effectiveness in COPD patients. In order to improve smoking cessation rates, this study sought to examine the effects of theory-based smoking cessation interventions on COPD patients. Methods Our research adopted a meta-analysis design. Two researchers conducted a search and evaluation of randomized controlled trials (RCTs) that met the inclusion criteria. The Cochrane Library, Web of Science, PubMed, Embase, Wanfang Knowledge Service Platform, China National Knowledge Infrastructure (CNKI), VIP Information Services Platform, and China Biomedical Literature Service System were among the databases that were searched. The retrieval deadline for this search is from the establishment of the database up until April 20, 2023. Results A total of 11 RCTs involving 3,830 patients were included in the meta-analysis. Results showed that theory-based smoking cessation interventions improved smoking cessation rates, quality of life, and lung function in COPD patients compared to conventional nursing. However, these interventions did not significantly affect the level of nicotine dependence in patients. Conclusion Theory-based smoking cessation intervention as a non-pharmacologically assisted smoking cessation strategy has a positive impact on motivating COPD patients to quit smoking and improving their lung function and quality of life.

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Effects of different interventions on smoking cessation in chronic obstructive pulmonary disease patients: A systematic review and network meta-analysis

Wang

Guo²,

Shang³

et al. 2022

International Journal of Nursing Studies

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The long-term outcomes of tobacco control strategies based on the cognitive intervention for smoking cessation in COPD patients

Cited by 8 publications

References 30 publications

FUT8-Mediated Core Fucosylation Promotes the Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension

FUT8-Mediated Core Fucosylation Promotes the Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension

The effectiveness of theory-based smoking cessation interventions in patients with chronic obstructive pulmonary disease: A meta-analysis

Effects of different interventions on smoking cessation in chronic obstructive pulmonary disease patients: A systematic review and network meta-analysis

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