All great truths begin as blasphemies.-George Bernard Shaw W e have observed a group of patients who do not display the typical carpal tunnel syndrome signs and symptoms. 1,2 Their main complaints are pain and allodynia, often not limited to the median nerve distribution, worsening at night, and above all, inability to make a full fist (Fig. 1, above and center). Despite the different presentation from the typical carpal tunnel syndrome patient, they respond equally well to carpal tunnel release (Fig. 1
, below).Apparently unrelated to the description above, or to a problem in the carpal canal, is the condition known as complex regional pain syndrome of the upper limb (also known as reflex sympathetic dystrophy, Sudeck disease, or algodystrophy). Its clinical picture is characterized by trophic and vasomotor changes and, above all, pain out of proportion, which may be constant, present at rest or with the slightest movement, and with varying severity of allodynia and hyperalgesia. Disturbed sleep is the norm. The hand appearance changes over time: initially red, warm, and swollen, it later becomes whiter, drier, cooler, and stiffer. [3][4][5][6][7][8][9][10] Despite the abundant literature and research, complex regional pain syndrome has an