The Long-Term Prognosis of AA and AL Renal Amyloidosis and the Pathogenesis of Chronic Renal Failure in Renal Amyloidosis*

Böhle, A.; Wehrmann, Manfred; Eissele, Rolf; Gise, H. v.; Mackensen-Haen, S; Ca, Müller; Müller, Gerhard A.

doi:10.1016/s0344-0338(11)80516-9

Cited by 33 publications

(27 citation statements)

References 33 publications

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“…Pavone-Macaluso (12) counted numerous MCs in the renal parenchyma of three biopsies from patients with amyloidosis associated with pyelonephritis. In contrast, Bohle et al (13) found only a few MCs in 11 biopsies from patients with AA FIGURE 6. Renal interstitial mast cells stained with anti-chymase (rhodamine-labeled, A) containing intracytoplasmic bFGF protein (FITC-labeled, B).…”

Section: Discussionmentioning

confidence: 92%

“…Pavao-Macalusco in 1960 (12) observed the presence of MCs in various renal diseases (including three cases of renal amyloidosis) using metachromatic staining. There is a general agreement that MCs increase in number in chronic diseases and in the progression of different renal lesions characterized by the presence of tubulointerstitial lesions, including interstitial fibrosis (8,10,11), which are considered as poor prognostic markers of various renal diseases including renal amyloidosis (13). Changes in the area of interstitial fibrosis correlate better than the amount of amyloid deposition with renal function (13).…”

mentioning

confidence: 99%

“…There is a general agreement that MCs increase in number in chronic diseases and in the progression of different renal lesions characterized by the presence of tubulointerstitial lesions, including interstitial fibrosis (8,10,11), which are considered as poor prognostic markers of various renal diseases including renal amyloidosis (13). Changes in the area of interstitial fibrosis correlate better than the amount of amyloid deposition with renal function (13). The pathologic changes induced by MCs are in part due to serine proteases synthesized and released by MCs, such as tryptase and chymase as well as other bioactive mediators, because these are mitogenic for fibroblasts and known to induce collagen synthesis (2,14,15).…”

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confidence: 99%

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Increased Density of Interstitial Mast Cells in Amyloid A Renal Amyloidosis

et al. 2000

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confidence: 92%

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Increased Density of Interstitial Mast Cells in Amyloid A Renal Amyloidosis

et al. 2000

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“…Bohle, et al reported that tubulointestinal damage in renal amyloidosis, and especially fibrosis, is an important determination of renal prognosis 8,9) . The rate of progression to renal failure is usually slow, but depends directly on the intensity of proteinuria and extension of amyloid deposits, especially in the vessels and tubules 10) .…”

Section: Discussionmentioning

confidence: 99%

A Long-Term Remission of Renal Amyloidosis With Nephrotic Syndrome After Autologous Peripheral Blood Stem-Cell Transplantation

Ogawa

Ikeda

Furukawa

et al. 2010

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: Renal amyloidosis is typically characterized by nephrotic syndrome, often with massive proteinuria and refractory peripheral edema. We report the case of a patient with renal amyloidosis associated with nephrotic syndrome who maintained remission for 6 years after undergoing highdose chemotherapy followed by autologous peripheral blood stem -cell transplantation (auto -PBSCT). The patient was a man aged in his 50s who had developed nephrotic syndrome. Bone marrow aspiration and kidney biopsy determined that the cause of the nephrotic syndrome was renal amyloidosis due to multiple myeloma, and the patient was admitted to our department in July 2003. After one course of chemotherapy, auto -PBSCT was performed in March 2004. Following transplantation, serum M -protein was no longer detectable from March 2005, and the patient achieved complete hematological remission. Subsequently, proteinuria decreased, serum albumin levels normalized, and nephrotic syndrome improved. As of 6 years after transplantation, in March 2010, the patient remained in remission, meaning that auto -PBSCT proved extremely effective as a treatment for renal amyloidosis in this case.

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“…The prognosis of these patients is significantly worse in cases with interstitial fibrosis and tubular atrophy, and the degree of tubulointerstitial injury shows a significant inverse correlation with the creatinine clearance (CrCl). [1] Analysis of urinary protein excretion pattern (UPEP) is important in determining and differentiating glomerular and tubular forms of renal abnormalities at an earlier stage by less invasive techniques. [2][3][4][5][6] In this study, we aimed to compare UPEP with renal morphological findings, and to find out whether UPEP can be a prognostic indicator of renal amyloidosis in children.…”

Section: Introductionmentioning

confidence: 99%