The long-term risk of cardiovascular events in patients following bariatric surgery compared to a non-surgical population with obesity and the general population: a comprehensive national cohort study

Hung, Shao-Lun; Chen, Chung-Yen; Chin, Wei-Leng; Lee, Cheng-Hung; Chen, Jian-Han

doi:10.1007/s00423-020-02027-2

Cited by 12 publications

(12 citation statements)

References 31 publications

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“…Next, Hung et al . (22) conducted a study on 2,872 subjects (1,436 individuals in each group) within 18–55 years old who had attempted conservative methods, had a BMI >35 kg/m 2 with comorbidities or >40 kg/m 2 and had no psychiatric disorders (e.g., major depression, anxiety or bulimia nervosa). The primary endpoint was hospitalization due to MI, intracranial hemorrhage, ischemic stroke or transient ischemic attack.…”

Section: Resultsmentioning

confidence: 99%

Reduction of Major Adverse Cardiovascular Events (MACE) after Bariatric Surgery in Obese Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis

Sutanto

2021

Preprint

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Cardiovascular diseases (CVDs) are the leading cause of death worldwide and obesity is a major risk factor which increases morbidity and mortality of CVDs. Lifestyle modifications (e.g., diet control, physical exercise and behavioral changes) have been the first-line managements of obesity for decades. Nonetheless, when such interventions fail, pharmacotherapies and bariatric surgery are considered. Interestingly, a sudden weight loss (e.g., due to bariatric surgery) could also increase mortality (i.e., obesity paradox). Thus, it remains unclear whether the bariatric-surgery-associated weight reduction in patients with obesity and CVDs is beneficial for the reduction of Major Adverse Cardiovascular Events (MACE). Here, we performed a systematic literature search and meta-analysis of published studies comparing the MACE in patients with obesity and CVDs underwent bariatric surgery with control patients (no surgery). Studies data, including odds ratio (OR), were pooled and analyzed in a meta-analysis using a random effect model. Ten studies with a total of 1,772,305 patients, consisted of 74,042 patients underwent any form of bariatric surgery and 1,698,263 patients with no-surgery, were included in the meta-analysis. A random effect model was employed for analysis and showed that bariatric surgery group had significantly lower odds of MACE as compared to no surgery (OR = 0.49; 95% CI 0.40-0.60; p<0.00001; I2=93%), suggesting the benefit of bariatric surgery in reducing the occurrence of MACE in obese patients with CVDs.

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Section: Resultsmentioning

confidence: 99%

Reduction of Major Adverse Cardiovascular Events (MACE) after Bariatric Surgery in Obese Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis

Sutanto

2021

Preprint

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“…Jahrhunderts. Es handelt sich um eine lebensbedrohliche und progressive Erkrankung mit dem Charakter einer Epidemie 1 .…”

Section: Epidemiologieunclassified

“…Eine Vielzahl von Studien belegt den Vorteil der metabolischen Chirurgie im Vergleich mit der konservativmedikamentösen Therapie des Diabetes mellitus Typ 2 1 – 4 .…”

Section: Introductionunclassified

Metabolische Chirurgie

Luderer¹

2022

Allgemein- und Viszeralchirurgie up2date

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“…Next, Hung et al [28] conducted a study on 2872 individuals (1436 individuals in each group) of 18-55 years old who had attempted conservative methods, had a BMI > 35 with comorbidities or >40 and had no psychiatric disorders (e.g., major depression, anxiety or bulimia nervosa). The primary endpoint was hospitalization due to MI, intracranial hemorrhage, ischemic stroke or transient ischemic attack.…”

Section: Highlights Of the Included Studiesmentioning

confidence: 99%

Reduction of Major Adverse Cardiovascular Events (MACE) after Bariatric Surgery in Patients with Obesity and Cardiovascular Diseases: A Systematic Review and Meta-Analysis

et al. 2021

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Cardiovascular diseases (CVDs) are the leading cause of death worldwide and obesity is a major risk factor that increases the morbidity and mortality of CVDs. Lifestyle modifications (e.g., diet control, physical exercise and behavioral changes) have been the first-line managements of obesity for decades. Nonetheless, when such interventions fail, pharmacotherapies and bariatric surgery are considered. Interestingly, a sudden weight loss (e.g., due to bariatric surgery) could also increase mortality. Thus, it remains unclear whether the bariatric surgery-associated weight reduction in patients with obesity and CVDs is beneficial for the reduction of Major Adverse Cardiovascular Events (MACE). Here, we performed a systematic literature search and meta-analysis of published studies comparing MACE in patients with obesity and CVDs who underwent bariatric surgery with control patients (no surgery). Eleven studies, with a total of 1,772,305 patients, which consisted of 74,042 patients who underwent any form of bariatric surgery and 1,698,263 patients with no surgery, were included in the systematic review. Next, the studies’ data, including odds ratio (OR) and adjusted hazard ratio (aHR), were pooled and analyzed in a meta-analysis using a random effect model. The meta-analysis of ten studies showed that the bariatric surgery group had significantly lower odds of MACE as compared to no surgery (OR = 0.49; 95% CI 0.40–0.60; p < 0.00001; I2 = 93%) and the adjustment to confounding variables in nine studies revealed consistent results (aHR = 0.57; 95% CI 0.49–0.66; p < 0.00001; I2 = 73%), suggesting the benefit of bariatric surgery in reducing the occurrence of MACE in patients with obesity and CVDs (PROSPERO ID: CRD42021274343).

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The long-term risk of cardiovascular events in patients following bariatric surgery compared to a non-surgical population with obesity and the general population: a comprehensive national cohort study

Cited by 12 publications

References 31 publications

Reduction of Major Adverse Cardiovascular Events (MACE) after Bariatric Surgery in Obese Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis

Reduction of Major Adverse Cardiovascular Events (MACE) after Bariatric Surgery in Obese Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis

Metabolische Chirurgie

Reduction of Major Adverse Cardiovascular Events (MACE) after Bariatric Surgery in Patients with Obesity and Cardiovascular Diseases: A Systematic Review and Meta-Analysis

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