The long way toward understanding host and viral determinants of therapeutic success in HCV infection

BackgroundTreatment of hepatitis C virus (HCV) infection based on peginterferon-α (pegIFNα) and ribavirin induces important changes in cytokine release and T cell activation.ObjectiveImmune response to pegIFNα-ribavirin therapy was explored in patients coinfected by HCV and HIV.MethodsConcentrations of 25 cytokines and CD8+ T cell activation were monitored in HCV/HIV coinfected patients classified as sustained virological responders (SVR, n=19) and non-responders (NR, n=11).ResultsHigh pretreatment concentrations of IP-10 (CXCL-10) and MCP-1 (CCL-2) were associated with a poor anti-HCV response. PegIFNα-ribavirin therapy increased CD8+ T cell activation and induced significant changes in levels of eleven cytokines related to both Th1 and Th2 responses in SVR (IL-1β, IL-1RA, IL-4, IL-5, IL-6, IL-7, IL-12p40/70, IL-13, IP-10, eotaxin, MCP-1) but of only six cytokines in NR (IL-1β, IL-2, IL-5, IL-12p40/70, IL-13, eotaxin). The highest rise in MIP-1β and MCP-1 levels was observed four weeks after anti-HCV treatment initiation in SVR compared to NR (p=0.002 and p=0.03, respectively), whereas a decrease in IL-8 concentration was associated with treatment failure (p= 0.052).ConclusionsHigher and broader cytokine responses to pegIFNα-ribavirin therapy were observed in SVR patients compared to NR. Changes in IL-8, MIP-1β, and MCP-1 serum concentrations may be associated with efficacy of pegIFNα- and ribavirin-based therapies in patients coinfected by HCV and HIV.

show abstract

Cytokine Response Associated With Hepatitis C Virus Clearance in Hiv Coinfected Patients Initiating Peg Interferon- Based Therapy.

Nguyen¹,

Niloofar²,

Rubbo³

et al. 2016

Mediterr J Hematol Infect Dis

Self Cite

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The long way toward understanding host and viral determinants of therapeutic success in HCV infection

Cited by 1 publication

References 20 publications

Cytokine Response Associated With Hepatitis C Virus Clearance in Hiv Coinfected Patients Initiating Peg Interferon- Based Therapy.

Cytokine Response Associated With Hepatitis C Virus Clearance in Hiv Coinfected Patients Initiating Peg Interferon- Based Therapy.

Contact Info

Product

Resources

About