The longitudinal relationship between cannabis use and hypertension

Abstract

Introduction The relationship between cannabis use and hypertension is not clear based on prior epidemiological studies. Thus, we examined this relationship over a 3‐year follow‐up period using a large population‐based sample from the USA. Methods Self‐reported longitudinal data were obtained from the National Epidemiologic Survey on Alcohol and Related Conditions Wave 1 (2001/2002) and Wave 2 (2004/2005). The sample was restricted to participants who did not report hypertension at baseline (n = 26 844; 51% 40 years and older, 51% female, 71% white). χ2‐tests were used to examine the distributions of confounders stratified by the incidence of hypertension. Thereafter, multiple logistic regression analyses were conducted to quantify the relationships between lifetime cannabis use, 12‐month cannabis use and 12‐month cannabis use frequency and incidence of hypertension while adjusting for confounders. Results Cannabis use was associated with a decreased incidence of hypertension in the unadjusted analyses. However, the relationships were confounded by age. After adjustment for all confounders, neither lifetime cannabis use (odds ratio, 95% confidence interval 0.89, 0.77 to 1.02), 12‐month cannabis use (0.78, 0.56 to 1.09) nor 12‐month cannabis use frequency [at least monthly use (0.85, 0.57 to 1.28) and less than monthly use (0.67, 0.40 to 1.11)] were associated above chance with the incidence of hypertension. Discussion and Conclusions Lifetime cannabis use, 12‐month cannabis use and 12‐month cannabis use frequency were not associated with the incidence of hypertension.

Association of cannabis use disorder with cardiovascular diseases: A two-sample Mendelian randomization study

“…Cannabis use was also related to depression development in adolescents (57). However, there was no strong evidence for the association between cannabis use, body mass index, blood lipid, and hypertension (58)(59)(60). The results of the IVW analysis were inconsistent with the results in the simple and weighted median sensitivity analyses.…”

Cannabis Use Is Inversely Associated with Metabolic Disorders in Hepatitis C-Infected Patients (ANRS CO22 Hepather Cohort)

“…Conversely, a case report highlighted potential benefits of cannabis use on blood pressure stability in the context of autonomic dysreflexia [ 41 ]. Recently, Haleem et al found no association between cannabis use and hypertension incidence in the United States’ National Epidemiologic Survey on Alcohol and Related Conditions [ 28 ]. Elsewhere, after three months of cannabis-based treatment, blood pressure declined in 26 older adults with hypertension [ 29 ].…”

“…In the general population, cannabis use tends to be associated with a lower risk of meeting the criteria for metabolic syndrome diagnosis [ 24 , 25 ], which may be mediated by a body weight-lowering effect of cannabis [ 25 ]. However, contrasting results have been observed for hypertension [ 26 , 27 , 28 , 29 ] and for dyslipidemia [ 30 ] when taken individually. These various points, and the fact that cannabis use is a modifiable factor, underline the need to explore the relationships between cannabis use and metabolic disorders in HCV-infected patients in order to (i) increase understanding about the mechanisms related to extrahepatic manifestations of HCV infection, and (ii) document the metabolic impacts of cannabis use, with a view to guiding further research that may benefit both HCV-infected and non-infected people.…”

Hypertensive Crisis-Related Hospitalizations and Subsequent Major Adverse Cardiac Events in Young Adults with Cannabis Use Disorder: A Nationwide Analysis

“…The available research on the effect of cannabis on blood pressure, on the other hand, appears to be contradictory. A large-population observational study showed no association of hypertension with cannabis use over a follow-up period of 12 months [ 7 ]. We evaluated the prevalence, causes, and effects of hypertensive crisis (HC) among young adults with cannabis use disorder (CUD+) to non-users in a retrospective analysis of a nationally representative cohort from the United States (US) (CUD-).…”