The Loss of Intracellular K⁺Ions from the Intact Ehrlich Ascites Carcinoma Cell Following Irradiation with 15 MeV Electrons and X-rays

Cytogenetics of Tephrosia II. Mutagenic effect of single, pre- and postirradiation treatments with EMS and MMS in Tephrosia purpurea.

“…They observed that gamma radiation (10, 20, 30kR) inhibited the uptake of [2H] EMS leading to low mutation frequency. That the radiation treatment alters the integrity and per meability of biological membranes, thus facilitating more uptake of chemical muta gens (Flemming et al 1968, Luse 1970 leading to pronounced synergistic effect is not supported by the present observations. The chromatid separation at mid prophase of mitosis is a strong deviation from the normal one, where the chromatids separate only at late metaphase , after some biochemical reaction takes place between the two sister chromatids (Sybenga 1974) .…”

Effect of radiotherapy upon enzymes of the glycolytic and related pathways in human uterine cancer

“…In addition to loss of nicotinamide, activation of enzymes by disruption of lysosomes appears to take place in irradiated cervical cancer tissue (Goldberg et al, 1967) and in exfoliated cancer cells obtained by vaginal irrigation (Goldberg et al, 1969;Goldberg, 1971). Leakage of pyruvate (Dose & Dose, 1962) and of K+ (Flemming et al, 1968) also indicate altered permeability of the cell, which must have profound consequences for its metabolic integrity.…”