The loudness dependence of auditory evoked potentials and effects of psychopathology and psychopharmacotherapy in psychiatric inpatients

Ostermann, Julia; Uhl, Idun; Köhler, Elke; Juckel, Georg; Norra, Christine

doi:10.1002/hup.2269

Cited by 21 publications

(8 citation statements)

References 54 publications

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“…Since then, the role that NMDA receptors play in LTP was found to extend outside of the hippocampus to anatomically early areas within the visual (Artola and Singer, 1987;Kirk et al, 2010) and auditory cortices (Kirk et al, 2010) using paradigms that include rapid, repetitive presentations of sensory stimuli (e.g., flashing visual checkerboards, trains of auditory tones). In addition, several studies have demonstrated reduced LTP in the visual and auditory cortices of individuals with mood disorders (Normann et al, 2007;Ostermann et al, 2012;Yeap et al, 2009). Taken together, these studies suggest that up-regulation of LTP via ketamine administration might serve as an important mechanistic process mediating ketamine's antidepressant effects.…”

Section: Ketamine and Long-term Potentiationmentioning

confidence: 99%

Electrophysiological biomarkers of antidepressant response to ketamine in treatment-resistant depression: Gamma power and long-term potentiation

Gilbert

Zarate

2020

Pharmacology Biochemistry and Behavior

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Over the last two decades, the discovery of ketamine's antidepressant properties has galvanized research into the neurobiology of treatment-resistant depression. Nevertheless, the mechanism of action underlying antidepressant response to ketamine remains unclear. This study reviews electrophysiological studies of ketamine's effects in individuals with depression as well as healthy controls, with a focus on two putative markers of synaptic potentiation: gamma oscillations and long-term potentiation. The review focuses on: 1) measures of gamma oscillations and power and their relationship to both acute, psychotomimetic drug effects as well as delayed antidepressant response in mood disorders; 2) changes in long-term potentiation as a promising measure of synaptic potentiation following ketamine administration; and 3) recent efforts to model antidepressant response to ketamine using novel computational modeling techniques, in particular the application of dynamic causal modeling to electrophysiological data. The latter promises to better characterize the mechanisms underlying ketamine's antidepressant effects.

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Section: Ketamine and Long-term Potentiationmentioning

confidence: 99%

Electrophysiological biomarkers of antidepressant response to ketamine in treatment-resistant depression: Gamma power and long-term potentiation

Gilbert

Zarate

2020

Pharmacology Biochemistry and Behavior

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“…On the other hand, studies in patients taking GABAerge medication show that they have both lower LDAEP levels (measured at Cz) (Ostermann et al, 2012) and cortical GABA levels measured by MRS after administration (Goddard et al, 2004). These results are limited to the occipital cortex, as this area was preferably examined for increased measurement quality.…”

Section: Discussionmentioning

confidence: 99%

Association between Cortical GABA and Loudness Dependence of Auditory Evoked Potentials (LDAEP) in Humans

Wyss

Tse

Boers

et al. 2018

International Journal of Neuropsychopharmacology

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Loudness dependence of auditory evoked potentials (LDAEP) is a widely used EEG-based biomarker for central serotonergic activity. Serotonin has been shown to be associated with different psychiatric disorders such as depression and schizophrenia. Despite its clinical significance, the underlying neurochemical mechanism of this promising marker is not fully understood, and further research is needed to improve its validity. Other neurotransmitters might have a significant impact on this measure. Thus, we assessed the inhibitory action through individual GABA/H20 concentrations and GABA/glutamate ratios by means of magnetic resonance spectroscopy at 3T in healthy subjects. The measurements were assessed in the primary auditory cortex to investigate the association with the LDAEP, whose generators are mainly in the primary auditory cortex. For the first time, this study examines the link between GABAergic neurotransmission and LDAEP, and the data preliminary show that GABA may not contribute to the generation of EEG-based LDAEP.

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“…The N1/P2 amplitude was then calculated as the difference of peak amplitudes between N1 and P2. The LDAEP of the scalp data (Cz) was calculated as a median exponential slope of the amplitudes of the single loudness levels, since this method can be regarded as most validated measure for the LDAEP after 30 years of research in this field [Hegerl and Juckel, ; Ostermann et al, ].…”

Section: Methodsmentioning

confidence: 99%

Serotonergic modulation of orbitofrontal activity and its relevance for decision making and impulsivity

Mavrogiorgou

Enzi

Klimm

et al. 2016

Human Brain Mapping

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This study revealed that low serotonergic activity as measured by a strong LDAEP was related to a high fMRI signal intensity of SFG/MO during immediate reward behavior which is related to impulsivity. Since this relationship was only found for the infralimbic medial and not for the middle or lateral part of the orbitofrontal cortex, an exclusive projection tract of the serotonergic system to this cortical region can be assumed to regulate impulsive reward-orientated decision making. Hum Brain Mapp 38:1507-1517, 2017. © 2016 Wiley Periodicals, Inc.

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The loudness dependence of auditory evoked potentials and effects of psychopathology and psychopharmacotherapy in psychiatric inpatients

Abstract: The LDAEP in patients is related to severity of psychopathologic syndromes irrespective of diagnosis. Chronic psychopharmacologic treatment may also differentially modulate the LDAEP, but longitudinal studies are needed.

Cited by 21 publications

References 54 publications

Electrophysiological biomarkers of antidepressant response to ketamine in treatment-resistant depression: Gamma power and long-term potentiation

Electrophysiological biomarkers of antidepressant response to ketamine in treatment-resistant depression: Gamma power and long-term potentiation

Association between Cortical GABA and Loudness Dependence of Auditory Evoked Potentials (LDAEP) in Humans

Serotonergic modulation of orbitofrontal activity and its relevance for decision making and impulsivity

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