The loudness dependence of the auditory evoked potential (LDAEP) in schizophrenia, bipolar disorder, major depressive disorder, anxiety disorder, and healthy controls

The translationally relevant mouse model of the 15q13.3 microdeletion syndrome reveals deficits in neuronal spike firing matching clinical neurophysiological biomarkers seen in schizophrenia

“…2003, Park et al . 2010). These include a decreased amplitude of auditory evoked potentials (AEP) at certain latencies following each pulse as well as deceased ratio of the second to the first pulse response ( T / C ratio).…”

Chronic modulation of serotonergic neurotransmission with sertraline attenuates the loudness dependence of the auditory evoked potential in healthy participants

“…For example, in vivo microdialysis studies have revealed that 5-HT levels in the primary auditory cortex modulate the LDAEP in animals (Juckel et al 1997;Wutzler et al 2008). Further, an altered LDAEP has been demonstrated in psychiatric disorders (and some subtypes) where the serotonergic system is implicated, including major depressive disorder (Fitzgerald et al 2009;Park et al 2010), schizophrenia (Juckel et al 2008a;Gudlowski et al 2009;Park et al 2010) and bipolar disorder (Park et al 2010). Indeed, a strong pre-treatment LDAEP has been associated with a greater decrease in depressive symptoms after 4 weeks of SSRI treatment (Gallinat et al 2000).…”

Psychophysiological Markers of Anxiety Disorders and Anxiety Symptoms

“…More specifically, the LDAEP is defined as the linear regression slope calculated from five amplitudes of N1/P2 components in response to increasing five auditory tones see Figure 2). Research has indicated that the LDAEP is inversely related to central serotonergic activity: a stronger LDAEP indicates lower serotonergic neurotransmission and vice versa (Juckel et al, 1999, Park et al 2010. Initial evidence that linked the LDAEP and the serotonergic system came from animal studies (O'Neill et al, 2008).…”

“…Reduced COMT activity caused by genetic polymorphisms was associated with a weaker LDAEP (Juckel et al, 2008). The LDAEP has been utilized to study dysfunctional serotonergic and dopaminergic activity in patients with GAD , PTSD (Park et al, 2010), schizophrenia or depression (Gallinat et al, 2000). Recently, Park and colleagues (2010) compared the results of the LDAEP in a variety of psychiatric patients including GAD, PTSD, panic disorder, bipolar depression, major depressive disorder (MDD), and schizophrenia.…”

“…Particularly, in this chapter, we introduced the loudness of the auditory evoked potential (LDAEP) as a possible psychophysiological marker that can be utilized in anxiety research. Our previous studies revealed that patients with different subtypes of anxiety disorders produced distinctive LDAEPs and that the LDAEP could play an important role in predicting the efficacy of selective serotonin reuptake inhibitor (SSRI) treatment in anxiety disorders (Park et al, 2010(Park et al, , 2011. We suggest that utilizing the LDAEP along with other various ERP components indicating neural and cognitive dysfunctions associated with anxiety disorders may enhance our understanding of the etiology and maintenance of anxiety disorders.…”