The Low-density Lipoprotein Receptor-related Protein 6 Pathway in the Treatment of Intestinal Barrier Dysfunction Induced by Hypoxia and Intestinal Microbiota through the Wnt/β-catenin Pathway

Liu, Zhihua; Li, Chao; Liu, Min; Song, Zhen; Moyer, Mary Pat; Su, Dan

doi:10.7150/ijbs.72283

Cited by 8 publications

(5 citation statements)

References 52 publications

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“…The membrane was incubated with the primary antibody overnight at 4°C and then incubated for 1 h with the secondary antibody in Tris‐Buffered Saline, 0.1% Tween 20 buffer for 4 h at 4°C. The membrane was developed by the enhanced chemiluminescence method (ECL kit; Pierce) [ 60 ].…”

Section: Methodsmentioning

confidence: 99%

A high‐salt diet induces synaptic loss and memory impairment via gut microbiota and butyrate in mice

Liu

Peng

Zhan

et al. 2023

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High‐salt diet (HSD)‐fed mice display cognitive impairment and lower synaptic proteins via changed gut microbiota composition and short‐chain fatty acids production. Gut microbiota from HSD‐fed mice impairs memory and synapse in normal salt diet‐fed mice. Butyrate treatment partially reverses memory impairment in HSD‐fed mice. Above all, this study indicates the important role of the gut microbiome and butyrate production in synaptic loss and memory impairment.

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Section: Methodsmentioning

confidence: 99%

A high‐salt diet induces synaptic loss and memory impairment via gut microbiota and butyrate in mice

Liu

Peng

Zhan

et al. 2023

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“…The Chinese herbal medicine Qingchang Wenzhong decoction has been proven to modulate gut microbiota and may further activate Wnt/β-catenin signals, thus promoting ISC renewal ( Sun et al, 2021 ). Another experiment indicated that gut microbiota dysbiosis and hypoxia can inhibit low-density lipoprotein receptor-related protein 6 (LRP6) and the Wnt/β-catenin pathway, while drugs targeting LRP6 can protect the intestinal barrier and restore the gut microbiota by regulating the Wnt/β-catenin pathway ( Liu et al, 2022 ). Since AA showed an abnormality in the regulation process of the Wnt/β-catenin pathway and a link with the intestinal system, we believe that the gut microbiota and metabolome are also associated with this abnormality.…”

Section: Gut Microbiome and Metabolome And Aamentioning

confidence: 99%

Gut microbiome, metabolome and alopecia areata

Liu,

Liu

2023

Front. Microbiol.

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Alopecia areata (AA) is a type of dermatological disease characterized by rapid and non-scarring hair loss of the scalp or body skin that may be related to genetic, immunological and physiological factors. It is now believed that AA is associated with oxidative stress, autoimmune disease, neuropsychological factors, pathogens, immune checkpoint inhibitors and microecological imbalance under the premise of host genetic susceptibility. In recent years, studies have revealed the significant role of the gut microbiome or metabolome in many aspects of human health. Diverse studies have revealed that the gut microbiome and metabolome have an important influence on skin conditions. This review highlights the relationship between AA and the gut microbiome or metabolome to provide novel directions for the prevention, clinical diagnosis and treatment of AA.

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“…Concomitantly, the dysbiosis leads to a depletion of butyrate-producing bacteria, inducing a metabolic switch in colonocytes. This switch, from the oxidation of butyrate towards glucose fermentation that consumes less O 2 , increases the O 2 -tension in the gut [ 24 ] contributing to a decrease of the integrity of the intestinal barrier [ 25 ]. In addition, the depletion of secondary bile acids also promotes inflammation [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

The multiplicity of thioredoxin systems meets the specific lifestyles of Clostridia

Anjou,

Lotoux,

Zhukova

et al. 2024

PLoS Pathog

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Cells are unceasingly confronted by oxidative stresses that oxidize proteins on their cysteines. The thioredoxin (Trx) system, which is a ubiquitous system for thiol and protein repair, is composed of a thioredoxin (TrxA) and a thioredoxin reductase (TrxB). TrxAs reduce disulfide bonds of oxidized proteins and are then usually recycled by a single pleiotropic NAD(P)H-dependent TrxB (NTR). In this work, we first analyzed the composition of Trx systems across Bacteria. Most bacteria have only one NTR, but organisms in some Phyla have several TrxBs. In Firmicutes, multiple TrxBs are observed only in Clostridia, with another peculiarity being the existence of ferredoxin-dependent TrxBs. We used Clostridioides difficile, a pathogenic sporulating anaerobic Firmicutes, as a model to investigate the biological relevance of TrxB multiplicity. Three TrxAs and three TrxBs are present in the 630Δerm strain. We showed that two systems are involved in the response to infection-related stresses, allowing the survival of vegetative cells exposed to oxygen, inflammation-related molecules and bile salts. A fourth TrxB copy present in some strains also contributes to the stress-response arsenal. One of the conserved stress-response Trx system was found to be present both in vegetative cells and in the spores and is under a dual transcriptional control by vegetative cell and sporulation sigma factors. This Trx system contributes to spore survival to hypochlorite and ensure proper germination in the presence of oxygen. Finally, we found that the third Trx system contributes to sporulation through the recycling of the glycine-reductase, a Stickland pathway enzyme that allows the consumption of glycine and contributes to sporulation. Altogether, we showed that Trx systems are produced under the control of various regulatory signals and respond to different regulatory networks. The multiplicity of Trx systems and the diversity of TrxBs most likely meet specific needs of Clostridia in adaptation to strong stress exposure, sporulation and Stickland pathways.

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The Low-density Lipoprotein Receptor-related Protein 6 Pathway in the Treatment of Intestinal Barrier Dysfunction Induced by Hypoxia and Intestinal Microbiota through the Wnt/β-catenin Pathway

Cited by 8 publications

References 52 publications

A high‐salt diet induces synaptic loss and memory impairment via gut microbiota and butyrate in mice

A high‐salt diet induces synaptic loss and memory impairment via gut microbiota and butyrate in mice

Gut microbiome, metabolome and alopecia areata

The multiplicity of thioredoxin systems meets the specific lifestyles of Clostridia

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