The lung as an endocrine organ

Ben-Harari, Ruben R.; Youdim, Moussa B. H.

doi:10.1016/0006-2952(83)90543-9

Cited by 11 publications

(2 citation statements)

References 121 publications

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“…The endothelial cells also rapidly deaminate the transported amines by type-A monoamine oxidase (14-16) (Km for deamination with norepinephrine as substrate is 430 ,uM), which is distinctly different from the type-B monoamine oxidase found in chromaffin cells (13). In this respect, the medullary endothelial cells behave like the endothelial cells from rat and rabbit lung (2,15,16).…”

Section: Discussionmentioning

confidence: 96%

Endothelial cells from bovine adrenal medulla develop capillary-like growth patterns in culture.

Banerjee¹,

Ornberg²,

Youdim³

et al. 1985

Proc. Natl. Acad. Sci. U.S.A.

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The endocrine barrier between chromaffin cells and the blood stream in the adrenal medulla is made of capillary endothelial cells. We have now succeeded in isolating endothelial cells from adrenal medullary tissue, which are probably derived from this barrier. These cells grow on plastic surfaces in the absence of special growth factors or collagen overlays and differentiate into organized structures quite similar to true capillaries. The cells contain factor VIII:R, a marker for endothelial cells, and form intercellular junctions characteristic of capillary endothelial cells. They also synthesize and secrete basal lamina structures and engage in transcytosis, a characteristic ultrastructural and functional combination of exocytosis and endocytosis across the thin endothelial cell processes. These endothelial cells can take up and deaminate catecholamines by A-type monoamine oxidase, an enzyme functionally distinct from the B-type monoamine oxidase found in chromaffin cells. These data indicate that the chromaffin cell and its endothelial cell neighbor may constitute the functional unit of catecholamine metabolism in the adrenal medulla.

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Section: Discussionmentioning

confidence: 96%

Endothelial cells from bovine adrenal medulla develop capillary-like growth patterns in culture.

Banerjee¹,

Ornberg²,

Youdim³

et al. 1985

Proc. Natl. Acad. Sci. U.S.A.

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“…The organ has different ways to deal with arriving hormones: inactivation or transformation and activation or no influence at all. Since the lung has a huge surface for blood exchange, it is likely a good place for hormones to pass and to be filtered, transformed, or inactivated [22].…”

Section: Is the Lung An Endocrine Organ?mentioning

confidence: 99%

Obesity and the Lung: What We Know Today

et al. 2020

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Obesity is becoming more and more prevalent especially in Western industrial nations. The understanding of adipose tissue as an endocrine organ as well as the detection of adipocytokines – hormones that are secreted from the adipose tissue – gave reason to examine the interactions between adipose tissue and target organs. These efforts have been intensified especially in the context of bariatric surgery as promising weight loss therapy. Interactions between the lung and adipose tissue have rarely been investigated and are not well understood. There are obvious mechanical effects of obesity on lung function explaining the associations between obesity and lung diseases, in particular obesity hypoventilation syndrome, obstructive sleep apnea syndrome, asthma, and chronic obstructive pulmonary disease. The rise in the prevalence of obesity affects the epidemiology of pulmonary diseases as well. The aim of this review is to summarize the current knowledge on interactions, associations, and consequences of obesity and weight loss on lung function and lung diseases. Based on these data, areas for future research are identified.

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Pulmonary uptake of bupivacaine in isolated perfused rat lung

Foth

Geng

Krug

et al. 1995

Naunyn-Schmiedeberg's Arch Pharmacol

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The ability of rat lung to remove the local anaesthetic drug bupivacaine from the blood was studied in isolated organs which were perfused either in an open (single-pass mode) or in a closed system (recirculating medium). Isolated perfused rat lungs exhibited a very low capacity to metabolize bupivacaine within 3 h during which the drug circulated continuously through the organ. The clearance values differed only by 0.2 ml/min from the control parameters in sham perfusions. The calculated extraction ratio was 0.2% and the elimination half-life was about 210 min. The volume of distribution of bupivacaine was 133 ml which remarkably surmounted the reference values obtained for sham perfusions. The distribution of bupivacaine into the pulmonary tissue was investigated applying the multiple indicator dilution technique to isolated lungs perfused in the single-pass mode. The mean elimination time of model compounds for distribution into the intravascular space, 14C-insulin, and the total water space, 3H-water, were 68 and 75 s at a flow rate of 6 ml/min. The volume of distribution was 5.9 ml for inulin and 6.5 ml for water. The mean transit time for concomitantly injected bupivacaine was 221 s and the volume of distribution was 14.4 ml. The respective parameters of sham perfusions performed without an isolated organ were substantially lower, i.e. mean elimination time 50, 50 and 61 s and distribution volume 4.9, 5.0 and 6.1 ml for inulin, water and bupivacaine.2+ f1p4

show abstract

The lung as an endocrine organ

Cited by 11 publications

References 121 publications

Endothelial cells from bovine adrenal medulla develop capillary-like growth patterns in culture.

Endothelial cells from bovine adrenal medulla develop capillary-like growth patterns in culture.

Obesity and the Lung: What We Know Today

Pulmonary uptake of bupivacaine in isolated perfused rat lung

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