The Lung Microbiome in COPD and Lung Cancer: Exploring the Potential of Metal-Based Drugs

O’Shaughnessy, Megan; Sheils, Orla; Baird, Anne-Marie

doi:10.3390/ijms241512296

Cited by 7 publications

(5 citation statements)

References 325 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, alterations in the lung microbiota have been associated with respiratory diseases such as asthma, chronic obstructive pulmonary disease, pneumonia, cystic fibrosis, and lung cancer (Fig. 2 ) [ 127 – 131 ]. Interestingly, a gut–lung axis has been described, indicating crosstalk between the microbiomes of the gut and lungs (Fig.…”

Section: Lung Microbiotamentioning

confidence: 99%

Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions

Hashimoto

2023

Mol Psychiatry

View full text Add to dashboard Cite

The human body harbors a diverse ecosystem of microorganisms, including bacteria, viruses, and fungi, collectively known as the microbiota. Current research is increasingly focusing on the potential association between the microbiota and various neuropsychiatric disorders. The microbiota resides in various parts of the body, such as the oral cavity, nasal passages, lungs, gut, skin, bladder, and vagina. The gut microbiota in the gastrointestinal tract has received particular attention due to its high abundance and its potential role in psychiatric and neurodegenerative disorders. However, the microbiota presents in other body tissues, though less abundant, also plays crucial role in immune system and human homeostasis, thus influencing the development and progression of neuropsychiatric disorders. For example, oral microbiota imbalance and associated periodontitis might increase the risk for neuropsychiatric disorders. Additionally, studies using the postmortem brain samples have detected the widespread presence of oral bacteria in the brains of patients with Alzheimer’s disease. This article provides an overview of the emerging role of the host microbiota in neuropsychiatric disorders and discusses future directions, such as underlying biological mechanisms, reliable biomarkers associated with the host microbiota, and microbiota-targeted interventions, for research in this field.

show abstract

Section: Lung Microbiotamentioning

confidence: 99%

Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions

Hashimoto

2023

Mol Psychiatry

View full text Add to dashboard Cite

show abstract

“…Recently, perturbations in the lung microbiome in the context of lung cancer have been described and may contribute to carcinogenesis. Three mechanisms by which dysbiosis may contribute to the development of lung cancer are (1) the development of chronic inflammation, (2) the dysregulation of the immune equilibrium in the lung, and (3) the activation of oncogenes [81] (Figure 2). In general, the alpha diversity (richness) of the lung microbiome is decreased in lung cancer compared to healthy controls [82][83][84].…”

Section: The Relationship Between the Lung Microbiome And Lung Cancer...mentioning

confidence: 99%

The Complex Role of the Microbiome in Non-Small Cell Lung Cancer Development and Progression

Souza,

Forder,

Pewarchuk

et al. 2023

Cells

View full text Add to dashboard Cite

In recent years, there has been a growing interest in the relationship between microorganisms in the surrounding environment and cancer cells. While the tumor microenvironment predominantly comprises cancer cells, stromal cells, and immune cells, emerging research highlights the significant contributions of microbial cells to tumor development and progression. Although the impact of the gut microbiome on treatment response in lung cancer is well established, recent investigations indicate complex roles of lung microbiota in lung cancer. This article focuses on recent findings on the human lung microbiome and its impacts in cancer development and progression. We delve into the characteristics of the lung microbiome and its influence on lung cancer development. Additionally, we explore the characteristics of the intratumoral microbiome, the metabolic interactions between lung tumor cells, and how microorganism-produced metabolites can contribute to cancer progression. Furthermore, we provide a comprehensive review of the current literature on the lung microbiome and its implications for the metastatic potential of tumor cells. Additionally, this review discusses the potential for therapeutic modulation of the microbiome to establish lung cancer prevention strategies and optimize lung cancer treatment.

show abstract

“…Fecal microbiota transplantation (FMT) and a high-fiber diet resulted in reduced local and systemic inflammation while also offering protection against alveolar destruction and cellular apoptosis [ 10 ]. A deeper understanding of the lung microbiome has the potential to improve our ability to diagnose and treat lung diseases, leading to better outcomes for patients [ 11 ]. This is achieved through fecal transplantation from donors whose microbial diversity is well-suited for this purpose.…”

Section: Introductionmentioning

confidence: 99%

Restoring the epigenetic landscape of lung microbiome: potential therapeutic approach for chronic respiratory diseases

KavianFar,

Taherkhani,

Ahmadi

et al. 2024

BMC Pulm Med

View full text Add to dashboard Cite

Background Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and bronchiectasis, present significant threats to global health. Recent studies have revealed the crucial role of the lung microbiome in the development of these diseases. Pathogens have evolved complex strategies to evade the immune response, with the manipulation of host cellular epigenetic mechanisms playing a pivotal role. There is existing evidence regarding the effects of Pseudomonas on epigenetic modifications and their association with pulmonary diseases. Therefore, this study aims to directly assess the connection between Pseudomonas abundance and chronic respiratory diseases. We hope that our findings will shed light on the molecular mechanisms behind lung pathogen infections. Methods We analyzed data from 366 participants, including individuals with COPD, acute exacerbations of COPD (AECOPD), bronchiectasis, and healthy individuals. Previous studies have given limited attention to the impact of Pseudomonas on these groups and their comparison with healthy individuals. Two independent datasets from different ethnic backgrounds were used for external validation. Each dataset separately analyzed bacteria at the genus level. Results The study reveals that Pseudomonas, a bacterium, was consistently found in high concentrations in all chronic lung disease datasets but it was present in very low abundance in the healthy datasets. This suggests that Pseudomonas may influence cellular mechanisms through epigenetics, contributing to the development and progression of chronic respiratory diseases. Conclusions This study emphasizes the importance of understanding the relationship between the lung microbiome, epigenetics, and the onset of chronic pulmonary disease. Enhanced recognition of molecular mechanisms and the impact of the microbiome on cellular functions, along with a better understanding of these concepts, can lead to improved diagnosis and treatment.

show abstract

The Lung Microbiome in COPD and Lung Cancer: Exploring the Potential of Metal-Based Drugs

Cited by 7 publications

References 325 publications

Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions

Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions

The Complex Role of the Microbiome in Non-Small Cell Lung Cancer Development and Progression

Restoring the epigenetic landscape of lung microbiome: potential therapeutic approach for chronic respiratory diseases

Contact Info

Product

Resources

About