The luteal phase after ovarian stimulation

Kolibianakis, Efstratios M.; Devroey, Paul

doi:10.1016/s1472-6483(11)60214-9

Cited by 63 publications

(26 citation statements)

References 116 publications

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“…Furthermore, a delay in the post-ovulatory rise in P 4 is associated with retarded conceptus development (Forde et al 2011a). Similarly, in women, following ovulation, P 4 , produced by the CL, induces secretory transformations of the endometrium (Bourgain et al 1990) and allows endometrial receptivity and embryo implantation (Kolibianakis & Devroey 2002). In the case of conception, trophoblastderived human chorionic gonadotrophin (hCG) prevents CL regression and amplifies steroid secretion that consequently decidualises the endometrial stroma and supports early embryonic development.…”

Section: Discussionmentioning

confidence: 99%

“…Exogenous supplemental progesterone (P 4 ), often extending up to week 12, is a common practice in IVF-stimulated cycles because of the associated luteal phase defects (Kolibianakis & Devroey 2002, Pritts & Atwood 2002, Kolibianakis et al 2003. Although the benefit of P 4 administration as luteal phase support has been well documented in IVF (Fatemi et al 2007), a question surrounds the optimum time for its discontinuation (Griesinger 2011) based on the results of a retrospective uncontrolled study of 400 pregnancies (Schmidt et al 2001) and two randomised trials (Nyboe Andersen et al 2002, Kyrou et al 2011, which suggest that supplementation beyond 4 weeks of gestation is unnecessary.…”

Section: Introductionmentioning

confidence: 99%

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Effect of follicular aspiration just before ovulation on corpus luteum characteristics, circulating progesterone concentrations and uterine receptivity in single-ovulating and superstimulated heifers

O'Hara

Scully²,

Maillo³

et al. 2012

Reproduction

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The aim of this study was to investigate, in unstimulated and superstimulated heifers, the effect of follicle aspiration just before ovulation on corpus luteum (CL) development, circulating progesterone (P 4 ) concentrations and the ability of the uterus to support embryo development. Following follicle aspiration or ovulation timed from GNRH administration, CL development was assessed by daily ultrasonography, and CL function was assessed in terms of the capacity to produce P 4 and the expression of genes involved in steroidogenesis in luteal tissue. The capacity of the uterine environment to support conceptus development was assessed following transfer and recovery of in vitro-produced embryos. Follicular aspiration just before the expected time of ovulation leads to a significant reduction in CL diameter, CL area and area of luteal tissue. This was associated with a decrease in circulating P 4 in both unstimulated and superstimulated heifers. Follicle aspiration leads to a reduction in conceptus length and area on day 14 in unstimulated heifers only. Follicle aspiration leads to a reduction in the expression of LHCGR in luteal tissue from unstimulated heifers compared with those in which the CL formed after ovulation. Superstimulation significantly reduced the expression of STAR in luteal tissue in both ovulated and follicle-aspirated heifers. In conclusion, in stimulated and unstimulated heifers, aspiration of the preovulatory dominant follicle(s) just before expected ovulation interferes with the subsequent formation and function of the CL, in terms of size and P 4 output and this, in turn, is associated with a reduced capacity of the uterus to support conceptus elongation in unstimulated heifers.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of follicular aspiration just before ovulation on corpus luteum characteristics, circulating progesterone concentrations and uterine receptivity in single-ovulating and superstimulated heifers

O'Hara

Scully²,

Maillo³

et al. 2012

Reproduction

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show abstract

“…The authors reported that on the day of embryo transfer, a high frequency of uterine contractions hindered the transfer outcome, possibly by expelling the embryos from the uterine cavity. Additionally, there was a negative correlation between the frequency of contractions and progesterone concentrations [ 3 ].…”

Section: Role Of Progesterone In Implantationmentioning

confidence: 93%

Progestogens in Infertility Practice

Patki

Sharma

2015

Progestogens in Obstetrics and Gynecology

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“…It has been suggested that such abnormalities might be induced by the high estradiol (E 2 ) levels during the early follicular phase of a stimulated cycle, resulting in an earlier expression of endometrial progesterone receptors (PR). This earlier expression might allow progesterone (P) to exert its effect on the endometrium prematurely (5). Support for this hypothesis stems from data on the kinetics of steroid endometrial receptors.…”

mentioning

confidence: 99%