The luteal phase in polycystic ovary syndrome during ovulation induction with human menopausal gonadotropin with human menopausal gonadotropin with and without leuprolide acetate

Bachus, KE; Hughes, CL; Haney, A.F.; Dodson, W. Scott

doi:10.1016/0020-7292(91)90370-k

Cited by 3 publications

(4 citation statements)

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“…The findings in this study are in contrast with earlier studies in normogonadotrophic anovulatory WHO group II women, which have concluded that the serum concentration of progesterone in the mid-luteal phase cannot be used to predict treatment outcome in gonadotrophin-or clomiphene citrate-induced cycles (Laufer et al, 1982;Bachus et al, 1990;Maclin et al, 1990;Ellenbogen et al, 1995). Figure 1 Live birth rates for all women as well as women with large follicles (15 mm) but no medium-sized follicles (12-14 mm) at end of stimulation according to their serum concentrations of progesterone in the mid-luteal phase.…”

Section: Discussioncontrasting

confidence: 99%

“…In reality, however, the only means for confirming ovulation is if a pregnancy occurs as no definitive diagnostic test of ovulation is available. Only a few studies have investigated the relationship between mid-luteal serum progesterone concentrations above that used as cut-off for defining ovulation and the chance of pregnancy in anovulatory World Health Organization (WHO) group II women undergoing ovulation-induction treatment, and none of these was able to demonstrate a positive association (Laufer et al, 1982;Bachus et al, 1990;Maclin et al, 1990;Ellenbogen et al, 1995). One of the reasons could be that the earlier studies did not analyse the results in relation to the number of follicles present.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mid-luteal progesterone concentrations are associated with live birth rates during ovulation induction

Arce

Balen

Platteau³

et al. 2011

Reproductive BioMedicine Online

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mid-luteal progesterone concentrations are associated with live birth rates during ovulation induction

Arce

Balen

Platteau³

et al. 2011

Reproductive BioMedicine Online

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“…In some cases, authors re‐publish the same trial but with further information, such as a larger number of patients or other outcome variables (Valimaki et al 1989; Ylikorkala et al 1990; Thomas & Cooke 1987b; Cooke & Thomas 1989; Fedele et al 1989b, 1990; Dodson et al 1989; Bachus et al 1990) or an expansion of the original sample (Dodson et al 1987, 1989). Factorial design trials, in which the same group of patients is randomised more than once, were registered as a single trial, but the different interventions are analysed separately.…”

Section: Resultsmentioning

confidence: 99%

Infertility treatment: from cookery to science. The epidemiology of randomised controlled trials

Vandekerckhove¹,

O'Donovan²,

Lilford³

et al. 1993

BJOG

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Objectives To review the epidemiology of published randomised controlled trials in infertility treatment over the last 25 years, with special emphasis on the number and quality of trials. Design Computer literature review by MEDLINE backed up by a manual search of 41 journals. Each trial was classified according to the methodology described and quality criteria. The results were recorded in a computer database. Odds ratios (OR) and confidence intervals (CI) were calculated where the data were sufficient. Subjects Couples suffering from primary or secondary infertility. The trials studied 33 761 patients overall. Setting Institute of Epidemiology and Health Services Research, Leeds. Results Five hundred and one randomised trials in male and female infertility treatment were identified between 1966 and 1990. Pregnancy was an outcome in 291 (58%) and these were the subject of detailed analysis. Two hundred and twenty‐four (77%) and 67 (23%) ‘pregnancy trials’ were concerned, respectively, with female and male infertility. Four per cent of the trials were preceded by a sample size calculation, and the average sample size was 96 patients (range 5–933); 700 patients per group would be required to demonstrate plausible success rates for most treatments. The method of randomisation was unstated or pseudo‐randomised in 206 (71%) of trials where pregnancy was an outcome. Only 29 (5.8%) of studies were multicentre. The method of confirmation of pregnancy was omitted for 70% of papers. Cross‐over design was used in 103 (21%) of cases. Meta‐analysis is possible for selected topics such as the use of anti‐oestrogens in idiopathic oligospermia and unexplained female infertility. Eight cases of double reporting were identified. Conclusions Trials using randomised methodology were relatively few in comparison with other branches of medicine, although their use is important in the evaluation of treatment for infertility as treatment‐independent pregnancy is common. It was encouraging to note that an exponential increase in the use of this methodology occurred during the last three years, especially in association with assisted conception techniques, and meta‐analysis has become possible for selected topics. However, many trials suffer from an unrealistically small sample size, inappropriate use of cross‐over design or pseudo‐randomisation. The trend towards properly controlled studies should be encouraged but these studies should be of improved quality and organised on a multicentre or even international basis.

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“…Moreover, combined therapy was associated with an increased risk of OHSS (95-99), but there are insufficient data to draw solid conclusions on miscarriage and multiple pregnancy rates (100)(101)(102). Therefore, the significantly higher hyperstimulation rate, the associated risk of multiple pregnancies, and the additional inconvenience and cost of concomitant GnRH agonist administration, in the absence of documented increases in pregnancy success, do not justify the routine use of GnRH agonists during ovulation induction with gonadotropins in PCOS patients.…”

Section: Combination Of Gnrh Analogues and Gonadotropinsmentioning

confidence: 96%

Consensus on infertility treatment related to polycystic ovary syndrome

Thessaloniki¹,

Greece²

2008

Fertility and Sterility

621

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The luteal phase in polycystic ovary syndrome during ovulation induction with human menopausal gonadotropin with human menopausal gonadotropin with and without leuprolide acetate

Cited by 3 publications

References 0 publications

Mid-luteal progesterone concentrations are associated with live birth rates during ovulation induction

Mid-luteal progesterone concentrations are associated with live birth rates during ovulation induction

Infertility treatment: from cookery to science. The epidemiology of randomised controlled trials

Consensus on infertility treatment related to polycystic ovary syndrome

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