The luteinizing hormone surge—the final stage in ovulation induction: modern aspects of ovulation triggering

Wallach, Edward E.; Shoham, Zeev; Schächter, M; Loumaye, Ernest; Weissman, Ariel; Macnamee, M.C.; Insler, V.

doi:10.1016/s0015-0282(16)57717-6

Cited by 96 publications

(11 citation statements)

References 123 publications

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“…Gonadotrophins are synthesized on rough endoplasmic reticulum in the gonadotrophic cells, packaged into secretory granules and stored. Actual secretion depends on migration and activation of the mature secretory granules at the cell membrane (Shoham et al, 1995).…”

Section: The Physiological Role Of Endogenous Progesterone In the Pitmentioning

confidence: 99%

Use of progestins to inhibit spontaneous ovulation during ovarian stimulation: the beginning of a new era?

Marca

Capuzzo

2019

Reproductive BioMedicine Online

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Section: The Physiological Role Of Endogenous Progesterone In the Pitmentioning

confidence: 99%

Use of progestins to inhibit spontaneous ovulation during ovarian stimulation: the beginning of a new era?

Marca

Capuzzo

2019

Reproductive BioMedicine Online

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“…In some clinical studies where endogenous LH was absent or inactive, recombinant human FSH alone allowed follicle development but with an inadequate estradiol concentration [22]. Although LH has essential and wellestablished roles in ovarian steroid synthesis and ovulation [23][24][25], the use of LH in superovulation treatments is controversial and unclear. Low LH levels might intensify FSH sensitivity in granulosa cells by increasing androgen synthesis during the early stage of folliculogenesis and this activity is required for normal follicle and oocyte development [26,27].…”

Section: Introductionmentioning

confidence: 99%

Effect of corifollitropin alfa supplemented with or without LH on ovarian stimulation and embryo viability in rabbit

et al. 2017

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There is increasing interest in using rabbits for research as a laboratory model as well as for industrial production of meat, wool and fur. Superovulation in animals is used to produce a maximum number of transferable embryos per donor, in order to either support genetic improvement programs, ex situ conservation or to optimize other biotechnologies. Over time, the use of this biotechnology has shown variable outcomes as a consequence of several factors, such as the origin of exogenous hormone, posology and the effect of gonadotropins used simultaneously, the donor and the environment. The aim of this study was to compare the efficacy of a single injection of corifollitropin alfa (CTP), alone or supplemented with LH, versus a FSH standard protocol of five equal doses administered twice daily to superovulate rabbit does (20 per group and 29 control females). We determined: 1) the impact of this stimulation on in vitro development and mRNA expression at blastocyst stage and 2) in vivo embryo development and viability rate at birth of transferred embryos. Our outcomes showed that the ovulation rate was similar among the different ovarian stimulation groups, reaching more than fourfold the ovulation rate of a control doe. While rates of embryos developing to the blastocyst stage after 48 h of in vitro culture were similar between groups, the hatched blastocyst rate was higher for superovulated embryos from CTP group. Moreover, no significant differences among mRNA expression of OCT4, SOX2 and NANOG genes were detected. Nevertheless, embryos from ovarian stimulated does with CTP + LH showed significantly higher implantation rates and survival at birth among the different ovarian stimulation groups and similar to those in the control group. In conclusion, the results of this study suggest that a single injection of long acting corifollitropin alfa can be effectively used in rabbits to elicit a more than fourfold increase in ovulation rate compared to control animals. In addition, the LH supplementation allows us to obtain similar in vivo embryo development results as in the control group.

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“…26 Progesterone is stimulated by the luteinizing hormone release, so it will also only begin to rise after the preovulatory phase and does so incrementally. 27,28 Current methods for computing catamenial epilepsy do not universally allow for these constants. They only count back from the onset of menses by 12 (or 17) days to define the luteal phase, then count forward from the onset of menses 9 days to define the follicular phase.…”

Section: How To Deal With Cycle Length Variability While Retaining Ph...mentioning

confidence: 99%

“…Estradiol increases, and when increased for 36 h, the gonadotropin surge is initiated and ovulation occurs 24 h later, making the preovulatory phase approximately 2–3 days long 26 . Progesterone is stimulated by the luteinizing hormone release, so it will also only begin to rise after the preovulatory phase and does so incrementally 27,28 …”

Section: Issues With Current Criteria and Possible Solutionsmentioning

confidence: 99%

Female sex steroids and epilepsy: Part 2. A practical and human focus on catamenial epilepsy

Alshakhouri,

Sharpe,

Bergin

et al. 2024

Epilepsia

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Catamenial epilepsy is the best described and most researched sex‐steroid specific seizure exacerbation. Yet despite this there are no current evidence based treatments nor an accepted diagnostic tool. The best tool we can currently have is tracking seizures over menstrual cycles however the reality of tracking seizures and menstrual cycles is fraught with challenges. In Part 1 (citation to be added on publication) of this two‐part review we outlined the often complex and reciprocal relationship between seizures and sex steroids. An adaptable means of tracking is required.In this review we outline the extent and limitations of current knowledge on catamenial epilepsy. We use example data to show how seizure exacerbations can be tracked in short/long and even irregular menstrual cycles. We describe how seizure severity, an often overlooked and under‐researched form of catamenial seizure exacerbation, can also be tracked.Finally, given the lack of treatment options for females profoundly affected by catamenial epilepsy, Section 3 focuses on current methods and models for researching sex steroids and seizures as well as limitations and future directions. To permit more informative, mechanism‐focussed research in humans, the need for both a consistent classification of catamenial epilepsy and an objective biomarker are highlighted.

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The luteinizing hormone surge—the final stage in ovulation induction: modern aspects of ovulation triggering

Cited by 96 publications

References 123 publications

Use of progestins to inhibit spontaneous ovulation during ovarian stimulation: the beginning of a new era?

Use of progestins to inhibit spontaneous ovulation during ovarian stimulation: the beginning of a new era?

Effect of corifollitropin alfa supplemented with or without LH on ovarian stimulation and embryo viability in rabbit

Female sex steroids and epilepsy: Part 2. A practical and human focus on catamenial epilepsy

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