The Lymphatic Endothelial Cell Secretome Inhibits Osteoblast Differentiation and Bone Formation
Ernesto Solorzano,
Andrew L. Alejo,
Hope C. Ball
et al.
Abstract:Complex lymphatic anomalies (CLAs) are a set of rare diseases with unique osteopathic profiles. Recent efforts have identified how lymphatic-specific somatic activating mutations can induce abnormal lymphatic formations that are capable of invading bone and inducing bone resorption. The abnormal bone resorption in CLA patients has been linked to overactive osteoclasts in areas with lymphatic invasions. Despite these findings, the mechanism associated with progressive bone loss in CLAs remains to be elucidated.… Show more
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