The Lymphatic System in Neurological Disease and Alzheimer's Disease. A Brief Editorial

Nitric Oxide as a Determinant of Human Longevity and Health Span

“…Food rich in L-arginine and antioxidants can exert potent anti-aging effects that increase health and fitness. Biomatrix precision supplementation uses nutrients that target the decisive metabolic pathways [40][41][42][43][44][45][46][47][48]. These are the arginine and tryptophan pathways, and they have to be rerouted [49][50][51][52][53][54][55][56][57][58][59][60].…”

“…Recent research has confirmed the decisive roles of these metabolic pathways in regulating and determining human health [40][41][42]. Exploring new avenues that enable active living and healthy aging by preserving our fitness throughout our entire lifetime is the ultimate aim and goal of ongoing research in the field [43][44][45][46][47][48]. The upregulation of NO bioavailability can prevent premature aging and neurodegeneration characterized by cognitive decline [49][50][51][52][53][54][55][56][57].…”

“…Supplementation with L-arginine and the B vitamins B 6 , folic acid, and B 12 can stop the vicious cycle [22,23]. Thus, tryptophan levels have to be selectively increased, for instance, by L-arginine or L-arginine-rich food that contains sufficient B vitamins, leading to enhanced formation of the antioxidant indole agents to boost NO bioactivity and bioavailability [22,23,[43][44][45][46][47]58,59]. Supplementation and dietary management of age-associated diseases target elevated blood pressure in the normal and high-normal range due to reduced endothelium-derived NO formation, reduced blood flow by improving endothelium-dependent NO-mediated vasodilation in the early stages of arteriosclerosis, and enhanced homocysteine levels by supplying sufficient folate, vitamin B 6 , and B 12 as needed [22,23,[43][44][45][46][47]58,59].…”

“…The studies on L-arginine-rich food have severe limitations due to size and scope, and they all lack the necessary power to provide proof of principle [44,47,58,59]. The small size of these studies does not allow us to arrive at any conclusion on the clinical relevance of augmented NO signaling, nor are the decisive molecular mechanisms and mediators of such supplementation fully identified and sufficiently characterized, pointing to the urgent need to conduct broad, large-scale clinical trials that address the complexity of the metabolic pathways involved in regulating NO bioavailability and bioactivity.…”

Nitric Oxide as a Determinant of Human Longevity and Health Span

“…Food rich in L-arginine and antioxidants can exert potent anti-aging effects that increase health and fitness. Biomatrix precision supplementation uses nutrients that target the decisive metabolic pathways [40][41][42][43][44][45][46][47][48]. These are the arginine and tryptophan pathways, and they have to be rerouted [49][50][51][52][53][54][55][56][57][58][59][60].…”