The lymphatic vasculature revisited

Kerjaschki, Dontscho

doi:10.1172/jci74854

Cited by 80 publications

(54 citation statements)

References 38 publications

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“…See also Supplemental Videos 2 and 3. (37). In our studies, the morphological structure and the colocalization in the lymph node, as work with M. tuberculosis granulomas has previously been shown in the lymph nodes of nonhuman primates (33) and the lungs of guinea pigs (34).…”

Section: Discussionsupporting

confidence: 69%

Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis

Lerner¹,

Carvalho-Wodarz²,

Repnik³

et al. 2016

Journal of Clinical Investigation

122

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Section: Discussionsupporting

confidence: 69%

Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis

Lerner¹,

Carvalho-Wodarz²,

Repnik³

et al. 2016

Journal of Clinical Investigation

122

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“…The lymphatic network plays an important role in inflammatory and autoimmune diseases, cancer, lymphedema, graft rejection, and wound healing 17, 18, 19. The concept that lymphatic vessels could influence atherogenesis and lipoprotein transport has first been brought forward several decades ago 20, 21, 22.…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein A‐I Modulates Atherosclerosis Through Lymphatic Vessel‐Dependent Mechanisms in Mice

Milasan

Jean

Dallaire

et al. 2017

JAHA

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BackgroundSubcutaneously injected lipid‐free apoA‐I (apolipoprotein A‐I) reduces accumulation of lipid and immune cells within the aortic root of hypercholesterolemic mice without increasing high‐density lipoprotein–cholesterol concentrations. Lymphatic vessels are now recognized as prerequisite players in the modulation of cholesterol removal from the artery wall in experimental conditions of plaque regression, and particular attention has been brought to the role of the collecting lymphatic vessels in early atherosclerosis‐related lymphatic dysfunction. In the present study, we address whether and how preservation of collecting lymphatic function contributes to the protective effect of apoA‐I.Methods and ResultsAtherosclerotic Ldlr −/− mice treated with low‐dose lipid‐free apoA‐I showed enhanced lymphatic transport and abrogated collecting lymphatic vessel permeability in atherosclerotic Ldlr −/− mice when compared with albumin‐control mice. Treatment of human lymphatic endothelial cells with apoA‐I increased the adhesion of human platelets on lymphatic endothelial cells, in a bridge‐like manner, a mechanism that could strengthen endothelial cell–cell junctions and limit atherosclerosis‐associated collecting lymphatic vessel dysfunction. Experiments performed with blood platelets isolated from apoA‐I‐treated Ldlr −/− mice revealed that apoA‐I decreased ex vivo platelet aggregation. This suggests that in vivo apoA‐I treatment limits platelet thrombotic potential in blood while maintaining the platelet activity needed to sustain adequate lymphatic function.ConclusionsAltogether, we bring forward a new pleiotropic role for apoA‐I in lymphatic function and unveil new potential therapeutic targets for the prevention and treatment of atherosclerosis.

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“…Indeed, as potential lymphangioblastic precursors, a large pool of CD14 + monocytes was identified in the circulation. These monocytes were found to constitutively express VEGFR‐3 and turn on expression of podoplanin and several other lymphatic markers when cultured for a prolonged period 25. In this context, it is noteworthy the presence of numerous VEGFR‐3 + infiltrating mononuclear cells found in pSS MSGs.…”

Section: Discussionmentioning

confidence: 92%

Mobilization of lymphatic endothelial precursor cells and lymphatic neovascularization in primary Sjögren's syndrome

Alunno

Ibba‐Manneschi

Bistoni

et al. 2016

J Cellular Molecular Medi

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Although lymphatic neovascularization may be a key feature of chronic inflammation, it is almost unexplored in primary Sjögren's syndrome (pSS). A recent study revealed a pro‐lymphangiogenic function of interleukin (IL)‐17, a leading player in pSS pathogenesis. The aims of the study were to investigate lymphangiogenic mediators and lymphatic vasculature in pSS, as well as their possible association with IL‐17. Circulating lymphatic endothelial precursor cells (LEPCs) and Th17 cells were enumerated in pSS patients and healthy donors. VEGF‐C and IL‐17 levels were assessed in paired serum samples. Lymphatic vasculature, VEGF‐C/VEGF receptor (VEGFR)‐3 and IL‐17 were evaluated in pSS minor salivary glands (MSGs) and compared with normal and non‐specific chronic sialadenitis (NSCS) MSGs. Circulating LEPCs were expanded in pSS and correlated with circulating Th17 cells, IL‐17 and VEGF‐C. In pSS MSGs, a newly formed lymphatic capillary network was found within periductal inflammatory infiltrates and the number of interlobular lymphatic vessels was significantly increased compared with normal and NSCS MSGs. Strong VEGF‐C expression was detected in pSS ductal epithelial cells and periductal inflammatory cells. Numerous VEGFR‐3+ infiltrating mononuclear cells were exclusively observed in pSS MSGs. VEGFR‐3 expression was strongly increased in lymphatic capillaries of pSS MSGs. IL‐17+ inflammatory cells were preferentially observed around lymphatic vessels in pSS MSGs. This study supports the notion that lymphvasculogenesis and lymphangiogenesis are active in pSS, thereby unmasking a novel aspect of disease pathogenesis. In addition, our results suggest another possible pathogenic role of IL‐17 in pSS, further supporting its therapeutic targeting in this disease.

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The lymphatic vasculature revisited

Cited by 80 publications

References 38 publications

Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis

Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis

Apolipoprotein A‐I Modulates Atherosclerosis Through Lymphatic Vessel‐Dependent Mechanisms in Mice

Mobilization of lymphatic endothelial precursor cells and lymphatic neovascularization in primary Sjögren's syndrome

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