The Lymphoma Hidden in Actinomycosis

Carneiro, Liliana; Ferreira, Rute; Pinto, João Correia

doi:10.1016/j.jpge.2015.12.005

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…This infection can resemble other chronic diseases or present as acute abdominal pain and often goes undiagnosed until surgery or obtaining biopsy results [11,12]. Actinomycosis can also mask malignancies, such as lymphomas, which may cause the initial mucosal injury producing the substrate for the microorganism to reproduce and invade [13,14]. In our patient, we think that a localized cecal actinomycosis hid the DLBCL.…”

Section: Discussionmentioning

confidence: 78%

Double Trouble: A Unique Case of Hypercalcemia Caused by Two Underlying Etiologies

Ordaya¹,

Arriola-Montenegro²,

Arriola-Montenegro³

et al. 2022

Cureus

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Hypercalcemia has a variety of causes, with primary hyperparathyroidism and malignancies being the most frequently reported. We present the case of a patient presenting with chronic abdominal pain, constipation, and weight loss who was found to have hypercalcemia. The patient was initially diagnosed with colonic actinomycosis, but further investigations revealed an intra-abdominal diffuse large B-cell lymphoma (DLBCL). We suspect that the leading cause of hypercalcemia was the DLBCL, likely exacerbated by actinomycosis. Actinomycosis and DLBCL can have a similar presentation, so misdiagnosis or coexistence of both conditions should be suspected when a lack of response to one specific therapy is observed.

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Section: Discussionmentioning

confidence: 78%

Double Trouble: A Unique Case of Hypercalcemia Caused by Two Underlying Etiologies

Ordaya¹,

Arriola-Montenegro²,

Arriola-Montenegro³

et al. 2022

Cureus

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“…High acid output in the stomach lumen prevents bacterial colonization. In most cases of gastric actinomycosis underlying diseases (tumors, ulcers) facilitate the formation of typical submucous abscesses [8][9][10].…”

Section: Discussionmentioning

confidence: 99%

Unusual presentations of actinomycosis: a case series and literature review

Skuhala

Vukelić

Desnica

et al. 2021

J Infect Dev Ctries

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Introduction: To review unusual actinomycosis cases that appeared as a diagnostic and therapeutic challenge at our institution and to present a literature review on the usual clinical presentations. Methodology: This retrospective review included all patients hospitalized for actinomycosis in a 10-year period at the University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, Zagreb, Croatia. Results: A total of 15 patients were hospitalized during the observed period, 9 (60%) females and 6 (40%) males. The localizations of actinomycosis were: pelvis (5), lungs (3), blood stream (2), colon (1), penis (1), stomach (1), skin (1), cervicofacial region (1). We present four unusual cases: subcutaneous actinomycotic abscess, actinomycosis of the stomach with underlying non-Hodgkin lymphoma, sepsis due to Actinomyces neslundii originated from chronic asymptomatic periapical tooth abscesses and actinomycosis of the distal part of the penile shaft. Conclusions: Actinomycosis was a very rare clinical problem in our clinical practice (0.032% of all hospitalizations and 0.0034% of all outpatients) but among those cases classical clinical presentations were also very rare.

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“…11,12 In many reported cases, actinomycosis has been misdiagnosed as malignancy in the initial presentation and has been called a 'great mimicker' in literature. 13,14 Concomitant actinomycosis and malignancy is a rare clinical entity with only eleven cases reported to date [15][16][17][18][19][20][21][22][23][24] (Table 1). Interestingly, including this case, 9 out of these 12 cases have involved haematological malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…Concomitant actinomycosis and malignancy is a rare clinical entity with only eleven cases reported to date 15–24 (Table 1). Interestingly, including this case, 9 out of these 12 cases have involved haematological malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…Carneiro et al 22 Gastric actinomycosis and diffuse large B-cell lymphoma Persistent abdominal pain, anorexia and significant weight loss Okuda et al 21 Left lung actinomycosis coexisting with right lung squamous cell carcinoma Chest pain and masses in both lung fields Dentale et al 18 Pulmonary actinomycosis and non-Hodgkin's lymphoma Ulcerative lesion in the hard palate Kang et al 19 Abdominal actinomycosis-and peripheral T-cell lymphoma…”

Section: Condition Presenting Complaintmentioning

confidence: 99%

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Masking and misleading: concomitant actinomycosis and B-cell lymphoma – a case report and review of literature

Lim

Wong²,

Leong³

et al. 2018

Scott Med J

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We report a 72-year-old patient who presented with an ulcerated palatal mass, weight loss and adrenal insufficiency. Repeated biopsies from the mass revealed actinomycosis with no features of malignancy, while computed tomography scanning revealed a left maxillary sinus mass with invasive features and bilateral large adrenal masses. Blood and urine investigations showed adrenal insufficiency. The patient was treated as actinomycosis with adrenal involvement and was given intravenous penicillin and intravenous hydrocortisone. However, his condition did not improve and new signs appeared, that of left facial swelling and lymphadenopathy. A repeat biopsy of the palatal and adrenal masses revealed B-cell lymphoma. This case highlights the possibility that actinomycosis and lymphoma may share similar clinical presentations and may coexist. Either may mask and/or mimic the other, thus causing a delay in diagnosis. We describe the clinical progress and review the related literature. Interestingly, 9 out of the 12 reported cases of concomitant actinomycosis and malignancy (including this case) involve haematological malignancy. A high index of suspicion and treatment response reassessment is important in the management of either rare clinical entity.

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The Lymphoma Hidden in Actinomycosis

Cited by 5 publications

References 5 publications

Double Trouble: A Unique Case of Hypercalcemia Caused by Two Underlying Etiologies

Double Trouble: A Unique Case of Hypercalcemia Caused by Two Underlying Etiologies

Unusual presentations of actinomycosis: a case series and literature review

Masking and misleading: concomitant actinomycosis and B-cell lymphoma – a case report and review of literature

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