The macamide relieves fatigue by acting as inhibitor of inflammatory response in exercising mice: From central to peripheral

Zhu, Hongkang; Wang, Ruoyong; Hua, Hanyi; Cheng, Yuliang; Guo, Yahui; Qian, He; Du, Peng

doi:10.1016/j.ejphar.2022.174758

Cited by 22 publications

(19 citation statements)

References 30 publications

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“…Our previous studies have proved the ameliorative influences of Maca treatment against exercise-induced fatigue via regulating mitochondrial respiration and oxidative stress [12,13]. Meanwhile, MCP has been demonstrated to function in alleviating fatigue, which encouraged our interest in investigating the influence of MCP on the intestinal microbiota, subject to exhaustion induced by acute exercise in the current study.…”

Section: Introductionmentioning

confidence: 84%

Network Pharmacology Exploration Reveals Gut Microbiota Modulation as a Common Therapeutic Mechanism for Anti-Fatigue Effect Treated with Maca Compounds Prescription

et al. 2022

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Maca compounds prescription (MCP) is a common botanical used in dietary supplements, primarily to treat exercise-induced fatigue. The aim of this study is to elucidate the multi-target mechanism of MCP on fatigue management via network pharmacology and gut microbiota analysis. Databases and literature were used to screen the chemical compounds and targets of MCP. Subsequently, 120 active ingredients and 116 fatigue-related targets played a cooperative role in managing fatigue, where several intestine-specific targets indicated the anti-fatigue mechanism of MCP might be closely related to its prebiotics of intestinal bacteria. Thus, forced swimming tests (FSTs) were carried and mice fecal samples were collected and analyzed by 16S rRNA sequencing. Gut microbiota were beneficially regulated in the MCP-treated group in phylum, genus and OTU levels, respectively, and that with a critical correlation included Lactobacillus and Candidatus Planktophila. The results systematically reveal that MCP acts against fatigue on multi-targets with different ingredients and reshapes the gut microbial ecosystem.

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Section: Introductionmentioning

confidence: 84%

Network Pharmacology Exploration Reveals Gut Microbiota Modulation as a Common Therapeutic Mechanism for Anti-Fatigue Effect Treated with Maca Compounds Prescription

et al. 2022

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“…Notably, the relative genus-level gut flora abundance of Lactobacillus is increased over 2.5 folds (51.4 vs 19.8%, MCP vs Ex group), and that of Candidatus _ Planktophila is decreased about 16 folds (2.2 vs 36.9%). Fatigue-related biochemical changes, as well as gut microbiota changes have been found their contributions to exercise mice performance ( 19 , 25 ). In particular, fatigue generation is proved as one of the consequences of gastrointestinal imbalance, which may be associated with host metabolism and intestinal microecology ( 26 ).…”

Section: Resultsmentioning

confidence: 99%

“…Fatigue were the most commonly reported systemic reactions, suggesting a link existed among fatigue-related parameters from central to peripheral ( 19 ). Intestinal dysbiosis can dysregulate inflammation of intestinal surrounding tissues as well as cognition and mood ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

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Deciphering the potential role of Maca compounds prescription influencing gut microbiota in the management of exercise-induced fatigue by integrative genomic analysis

et al. 2022

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A growing number of nutraceuticals and cosmeceuticals have been utilized for millennia as anti-fatigue supplements in folk medicine. However, the anti-fatigue mechanism underlying is still far from being clearly explained. The aim of the study is to explore the underlying mechanism of the Maca compound preparation (MCP), a prescription for management of exercise-induced fatigue. In this study, mice weight-loaded swimming test was used to evaluate the anti-fatigue effect of MCP. MCP significantly improved the forelimb grip strength and Rota-rod test in behavioral tests via regulating energy metabolism. 16S rDNA sequencing results showed MCP can regulate the intestinal flora at the genus level by increasing several beneficial bacteria (i.e., Lactobacillus, Akkermansia and etc.), and decreasing the harmful bacteria (i.e., Candidatus_Planktophila and Candidatus_Arthromitus), where notable high relevance was observed between the fatigue-related biomarkers and fecal microbiota. The results of microbial function analysis suggested that MCP might improve exercise-induced fatigue by enhancing energy metabolism, carbohydrate and lipid metabolism and metabolism of terpenoids and polyketides and breakdown of amino acid metabolism. In addition, and H2O2-induced oxidative stress model on C2C12 cells was employed to further validate the regulation of MCP on energy metabolisms. MCP pre-treatment significantly reduced intracellular ROS accumulation, and increased glycogen content, ATP generation capacity and mitochondrial membrane potential of skeletal muscle cells, as well as conferred anti-cell necrosis ability. In conclusion, MCP plays a key role in regulating fatigue occurrence in exercising and gut microbiota balance, which may be of particular importance in the case of manual workers or sub-healthy populations.

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“…High-altitude plants with anti-inflammatory activities, such as ethanoic extract from Maca [ 60 ], significantly inhibited the activities of TNF-α, IL-6, and IL-1β, and alleviated exercise-induced fatigue. In addition, macamides could also interacted the expression of analog of exogenous anandamide (AEA) and receptor (CB 1 ) [ 32 ], so that it might reduce exercise-induced inflammatory nociception mediated by endocannabinoid [ 61 , 62 ]. IL-10 is an anti-inflammatory cytokine that can reduce antigen presentation, negatively regulating the activity of pro-inflammatory cytokines.…”

Section: Pharmacological Effects On Treatment Of Fatigue-related Diso...mentioning

confidence: 99%

Pharmaceutical Potential of High-Altitude Plants for Fatigue-Related Disorders: A Review

Zhu

Liu

Qian

2022

Plants

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Natural plants from plateaus have been the richest source of secondary metabolites extensively used in traditional and modern health care systems. They were submitted to years of natural selection, co-evolved within that habitat, and show significant anti-fatigue-related pharmacological effects. However, currently, no review on high-altitude plants with anti-fatigue related properties has been published yet. This study summarized several Chinese traditional high-altitude plants, including Rhodiola rosea L., Crocus sativus L., Lepidium meyenii W., Hippophaerhamnoides L., which are widely used in the Qinghai–Tibet Plateau and surrounding mountains, as well as herbal markets in the plains. Based on phytopharmacology studies, deeper questions can be further revealed regarding how these plants regulate fatigue and related mental or physical disease conditions. Many active derivatives in high-altitude medical plants show therapeutic potential for the management of fatigue and related disorders. Therefore, high-altitude plants significantly relieve central or peripheral fatigue by acting as neuroprotective agents, energy supplements, metabolism regulators, antioxidant, and inflammatory response inhibitors. Their applications on the highland or flatland and prospects in natural medicine are further forecast, which may open treatments to reduce or prevent fatigue-related disorders in populations with sub-optimal health.

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The macamide relieves fatigue by acting as inhibitor of inflammatory response in exercising mice: From central to peripheral

Cited by 22 publications

References 30 publications

Network Pharmacology Exploration Reveals Gut Microbiota Modulation as a Common Therapeutic Mechanism for Anti-Fatigue Effect Treated with Maca Compounds Prescription

Network Pharmacology Exploration Reveals Gut Microbiota Modulation as a Common Therapeutic Mechanism for Anti-Fatigue Effect Treated with Maca Compounds Prescription

Deciphering the potential role of Maca compounds prescription influencing gut microbiota in the management of exercise-induced fatigue by integrative genomic analysis

Pharmaceutical Potential of High-Altitude Plants for Fatigue-Related Disorders: A Review

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