The macro and microvasculature of the dura mater

Kerber, Charles W.; Newton, Thomas H.

doi:10.1007/bf00335317

Cited by 234 publications

(99 citation statements)

References 11 publications

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“…Since, in our model, the major effect of the antimigraine drugs is on the arteriovenous anastomoses, we have used intracarotid injection of radioactive microspheres of different sizes to measure directly arteriovenous anastomotic blood flow in different tissues, including the dura mater. In concordance with the human dura mater (Rowbotham & Little, 1965;Kerber & Newton, 1973), arteriovenous anastomoses with a diameter between 28 and 90 gtm could be functionally demonstrated in the porcine dura mater. This is different from the dog dura mater, where there was no difference in entrapment between 15 and 50 im microspheres (Faraci et al, 1989), although, as in our experiments, the animals were anaesthetized with pentobarbitone, which is known to increase shunting (Forsyth & Hofibrand, 1970).…”

Section: Effects Of the Antimigraine Drugssupporting

confidence: 59%

“…A further location of arteriovenous anastomoses is the human dura mater (Rowbotham & Little, 1965;Kerber & Newton, 1973). This tissue is currently believed to play a role in the generation of the pain during a migraine attack.…”

Section: Effects Of the Antimigraine Drugsmentioning

confidence: 99%

“…For example, sumatriptan, which constricts pial vessels upon perivascular application in anaesthetized cats, fails to do so after intravenous administration (Humphrey et al, 1991a): this may be caused by its inability to cross the blood brain barrier (Sleight et al, 1990). However, the dura mater is devoid of an anatomical and functional blood-brain barrier, having fenestrated endothelium (Wislocki & Leduc, 1952;Knudsen et al, 1988 (Kerber & Newton, 1973). A constrictor action of sumatriptan, ergotamine and dihydroergotamine has been demonstrated on large arteries in the cranial vasculature, both in vitro (Muller-Schweinitzer & Weidmann, 1978;Parsons et al, 1989) and in vivo during migraine attacks (Friberg et al, 1991;Caekebeke et al, 1991).…”

Section: Effects Of the Antimigraine Drugsmentioning

confidence: 99%

“…A possible contribution of dilatation of arteriovenous anastomoses to the migraine headache has been postulated by Heyck (1969), who found the jugular venous oxygen saturation to be elevated during a migraine attack. Interestingly, arteriovenous anastomoses have been anatomically located in the human dura mater, which is endowed with rich vascularization (Rowbotham & Little, 1965;Kerber & Newton, 1973). The dura mater is currently held as a possible origin of the migraine pain, involving vasodilatation and extravasation of plasma protein, induced by peptide release from the peripheral endings of the trigeminal nerve (Markowitz et al, 1988;Goadsby et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

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Lack of effect of the antimigraine drugs, sumatriptan, ergotamine and dihydroergotamine on arteriovenous anastomotic shunting in the dura mater of the pig

Boer

Somers

Saxena

1992

British J Pharmacology

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1 In anaesthetized animals, the antimigraine drugs, sumatriptan, ergotamine and dihydroergotamine, reduce carotid arteriovenous anastomotic shunting. Within the carotid vascular bed arteriovenous anastomoses are located, amongst other places in the dura mater, which is a putative site of the pain during a migraine attack. 2 In this investigation, we have localized and measured the arteriovenous shunting within the carotid vascular bed of the pig by using simultaneous intracarotid injections of radiolabelled microspheres of three different sizes (10, 15 and 50gm), which provides an index of blood flow via arteriovenous anastomoses larger than approximately 14, 27 and 90 gm diameter, respectively. The effects of sumatriptan (0.3 mg kg-'), ergotamine (0.02 mg kg-'), dihydroergotamine (0.1 mg kg-') and saline were studied by repeating the injections of 15 and 50 gm spheres after the treatments. 3 There was no difference in shunting or entrapment between the 10 and 15 gm microsphere, indicating the absence of arteriovenous anastomoses with a diameter between 14 and 27 gm. 4 Arteriovenous anastomoses with a diameter between 27 and 90 gm, as indicated by the difference in blood flow measured by 15 and 50 gm spheres, were located in the dura mater, ears, skin, fat and, to a lesser extent, in the skeletal muscles and eyes. 5 Sumatriptan, ergotamine and dihydroergotamine reduced the overall flow in the smaller arteriovenous anastomoses (diameter between 27 and 90 gm), and even more in larger shunts (wider than 90 gm).6 Locally, blood flow in the smaller arteriovenous shunts was reduced in the skin and fat, but not in the dura mater, ears, eyes and muscles. It is not possible to determine in which tissues blood flow in the larger arteriovenous anastomoses was reduced. 7 Tissue blood flow measured with 15 gm microspheres remained unchanged after the three antimigraine drugs, implying a lack of effect on capillary flow. 8 It is concluded that in the anaesthetized pigs the only evident effect of these antimigraine drugs on carotid haemodynamics is a decrease in blood flow in both smaller and larger arteriovenous anastomoses; the smaller arteriovenous anastomoses were affected in the skin and fat, but not in other tissues.

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Section: Effects Of the Antimigraine Drugssupporting

confidence: 59%

Section: Effects Of the Antimigraine Drugsmentioning

confidence: 99%

Section: Effects Of the Antimigraine Drugsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lack of effect of the antimigraine drugs, sumatriptan, ergotamine and dihydroergotamine on arteriovenous anastomotic shunting in the dura mater of the pig

Boer

Somers

Saxena

1992

British J Pharmacology

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“…In contrast to other intracranial dural venous sinuses, the CS is located extradurally, not between the periosteal and meningeal layers. 17,18 Due to its many routes of venous drainage, the presenting symptoms and signs of a CS DAVF are often benign. 46 These symptoms include blurred vision, bruit, diplopia, exophthalmos, chemosis, and glaucoma.…”

Section: Comparison Of Cs Davfs and Ncs Davfsmentioning

confidence: 99%

Stereotactic radiosurgery for intracranial dural arteriovenous fistulas: a systematic review

Chen¹,

Lee

Ding³

et al. 2015

JNS

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C urrent treatment strategies for intracranial dural arteriovenous fistulas (DAVFs) include microsurgical ligation, transarterial or transvenous embolization, stereotactic radiosurgery (SRS), and various combinations of these therapeutic options. Endovascular therapy, most commonly performed via transvenous routes, has become the preferred treatment approach for DAVFs. 27,44,48 Due to the immediate obliteration that can be achieved with endovascular or surgical occlusion, SRS is typically reserved for lesions that cannot be obliterated with endovascular or surgical approaches, or for patients who pose a high surgical risk due to medical comorbidities. Therefore, published SRS series for DAVFs remain relatively few and comprise mostly retrospective, single-center studies.In this systematic review, we evaluate the obliteration rate of DAVFs in patients treated with SRS. We also compare obliteration rates between cavernous sinus (CS) and noncavernous sinus (NCS) DAVFs, and between DAVFs with and without cortical venous drainage (CVD), by using available data in the literature. Methods inclusion CriteriaIn our attempt to balance between the largest possible patient population and a relatively homogeneous cohort, the following inclusion criteria for this systematic review were devised: 1) the study must contain at least 5 patients abbreviatioNs AVM = arteriovenous malformation; CS = cavernous sinus; CVD = cortical venous drainage; DAVF = dural arteriovenous fistula; GKS = Gamma Knife surgery; LINAC = linear accelerator; NCS = noncavernous sinus; SRS = stereotactic radiosurgery; TSS = transverse and sigmoid sinus. obJeCt The goal of this study was to evaluate the obliteration rate of intracranial dural arteriovenous fistulas (DAVFs) in patients treated with stereotactic radiosurgery (SRS), and to compare obliteration rates between cavernous sinus (CS) and noncavernous sinus (NCS) DAVFs, and between DAVFs with and without cortical venous drainage (CVD). Methods A systematic literature review was performed using PubMed. The CS DAVFs and the NCS DAVFs were categorized using the Barrow and Borden classification systems, respectively. The DAVFs were also categorized by location and by the presence of CVD. Statistical analyses of pooled data were conducted to assess complete obliteration rates in CS and NCS DAVFs, and in DAVFs with and without CVD. results Nineteen studies were included, comprising 729 patients harboring 743 DAVFs treated with SRS. The mean obliteration rate was 63% (95% CI 52.4%-73.6%). Complete obliteration for CS and NCS DAVFs was achieved in 73% and 58% of patients, respectively. No significant difference in obliteration rates between CS and NCS DAVFs was found (OR 1.72, 95% CI 0.66-4.46; p = 0.27). Complete obliteration in DAVFs with and without CVD was observed in 56% and 75% of patients, respectively. A significantly higher obliteration rate was observed in DAVFs without CVD compared with DAVFs with CVD (OR 2.37, 95% CI 1.07-5.28; p = 0.03). CoNClusioNs Treatment with SRS offers favorable rates of D...

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Functional Anatomy of Trigeminovascular Pain

Meßlinger

Dux

2017

Neurobiological Basis of Migraine

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The macro and microvasculature of the dura mater

Cited by 234 publications

References 11 publications

Lack of effect of the antimigraine drugs, sumatriptan, ergotamine and dihydroergotamine on arteriovenous anastomotic shunting in the dura mater of the pig

Lack of effect of the antimigraine drugs, sumatriptan, ergotamine and dihydroergotamine on arteriovenous anastomotic shunting in the dura mater of the pig

Stereotactic radiosurgery for intracranial dural arteriovenous fistulas: a systematic review

Functional Anatomy of Trigeminovascular Pain

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