The Macrophage Activation Marker Soluble CD163 is Associated With Early Allograft Dysfunction After Liver Transplantation

Thomsen, Karen Louise; Robertson, Francis P.; Holland-Fischer, Peter; Davidson, Brian R; Mookerjee, R.; Møller, Holger Jon; Jalan, Rajiv; Grønbæk, Henning

doi:10.1016/j.jceh.2018.09.006

Cited by 7 publications

(5 citation statements)

References 53 publications

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“…Besides, using sCD163 as a marker increased the prediction accuracy of poor outcomes of PBC. The sCD163 levels were also elevated in patients with early allograft dysfunction after liver transplantation, as macrophages were activated in the implanted liver when exposed to ischemia and reperfusion injury ( 67 ).…”

Section: Prognostic Markersmentioning

confidence: 99%

Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms

2021

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Tissue-resident macrophages (TRMs) are heterogeneous populations originating either from monocytes or embryonic progenitors, and distribute in lymphoid and non-lymphoid tissues. TRMs play diverse roles in many physiological processes, including metabolic function, clearance of cellular debris, and tissue remodeling and defense. Macrophages can be polarized to different functional phenotypes depending on their origin and tissue microenvironment. Specific macrophage subpopulations are associated with disease progression. In studies of fate-mapping and single-cell RNA sequencing methodologies, several critical molecules have been identified to induce the change of macrophage function. These molecules are potential markers for diagnosis and selective targets for novel macrophage-mediated treatment. In this review, we discuss some of the recent findings regarding less-known molecules and new functions of well-known molecules. Understanding the mechanisms of these molecules in macrophages has the potential to yield new macrophage-mediated treatments or diagnostic approaches to disease.

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Section: Prognostic Markersmentioning

confidence: 99%

Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms

2021

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“…Under the stimulation of long-term inflammation, liver macrophages would be activated to varying degrees ( 42 ). CD163, a scavenger receptor expressed only in monocytes and macrophages, was upregulated and entered the blood circulation as soluble CD163 (sCD163) under macrophage proliferation and activation conditions ( 43 ). During cirrhosis, Kupffer cells were also activated in patients with cirrhosis and portal hypertension.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric-analysis visualization and review of non-invasive methods for monitoring and managing the portal hypertension

Sun

Ni²,

Xue³

et al. 2022

Front. Med.

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“…Similarly, macrophage activation has been reported in other solid organ transplantations. Soluble CD163 levels were significantly increased in patients with early liver allograft dysfunction compared with patients with stable allograft function [ 35 ]. Moreover, Schreurs et al.…”

Section: Discussionmentioning

confidence: 99%

Increased macrophage activation marker soluble CD163 is associated with graft dysfunction and metabolic derangements in renal transplant recipients

et al. 2021

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The Macrophage Activation Marker Soluble CD163 is Associated With Early Allograft Dysfunction After Liver Transplantation

Cited by 7 publications

References 53 publications

Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms

Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms

Bibliometric-analysis visualization and review of non-invasive methods for monitoring and managing the portal hypertension

Increased macrophage activation marker soluble CD163 is associated with graft dysfunction and metabolic derangements in renal transplant recipients

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