The Magnetic Resonance Imaging in Active Surveillance (MRIAS) Trial: Use of Baseline Multiparametric Magnetic Resonance Imaging and Saturation Biopsy to Reduce the Frequency of Surveillance Prostate Biopsies

Amin, Amer; Scheltema, Matthijs J.; Shnier, Ron; Blazevski, Alexandar; Moses, Daniel; Cusick, Thomas W.; Siriwardena, Amila; Yuen, Brian; Leeuwen, Pim J. van; Haynes, Anne Maree; Matthews, Jayne; Brenner, Phillip; O’Neill, Gordon F.; Yuen, Carlo; Delprado, Warick; Stricker, Phillip D.; Thompson, James

doi:10.1097/ju.0000000000000693

Cited by 54 publications

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“…A total of 28 references were retrieved for a comprehensive evaluation. Seven studies were included in quantitative analysis [17][18][19][20][21][22]. The PRISMA flow chart is shown in Fig.…”

Section: Literature Searchmentioning

confidence: 99%

“…The PRISMA flow chart is shown in Fig. 1 Included studies Three studies were prospective cohort studies [17,22,23]. Four studies were retrospective in nature [18][19][20][21][22][23].…”

Section: Literature Searchmentioning

confidence: 99%

“…In six studies 3 T MRI was used [17][18][19][20][21]23], and in one study 1.5 T MRI was used [22]. Five studies used PIRADS v.2 or Likert scale for prostate lesions [17,18,21,[19][20][21][22][23]. Two studies used an independent scoring system [19,20].…”

Section: Literature Searchmentioning

confidence: 99%

“…Index test-mp-MRI All seven studies were used for a meta-analysis of diagnostic accuracy of mp-MRI [17][18][19][20][21][22].…”

Section: Sensitivity and Specificity Analysismentioning

confidence: 99%

See 3 more Smart Citations

Can the Use of Serial Multiparametric Magnetic Resonance Imaging During Active Surveillance of Prostate Cancer Avoid the Need for Prostate Biopsies?—A Systematic Diagnostic Test Accuracy Review

Hettiarachchi

Geraghty

Rice

et al. 2021

European Urology Oncology

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Section: Literature Searchmentioning

confidence: 99%

“…The PRISMA flow chart is shown in Fig. 1 Included studies Three studies were prospective cohort studies [17,22,23]. Four studies were retrospective in nature [18][19][20][21][22][23].…”

Section: Literature Searchmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

“…Index test-mp-MRI All seven studies were used for a meta-analysis of diagnostic accuracy of mp-MRI [17][18][19][20][21][22].…”

Section: Sensitivity and Specificity Analysismentioning

confidence: 99%

See 2 more Smart Citations

Can the Use of Serial Multiparametric Magnetic Resonance Imaging During Active Surveillance of Prostate Cancer Avoid the Need for Prostate Biopsies?—A Systematic Diagnostic Test Accuracy Review

Hettiarachchi

Geraghty

Rice

et al. 2021

European Urology Oncology

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“…Die PSA Dichte basierend auf der MRT Volumenmessung der Prostata ist ein weiterer relevanter Parameter zur Risikostratifikation [2]. Beide diagnostischen Methoden machen häufigere Biopsien verzichtbar [3]. Nach Ansicht der Autoren der MRI-AS Studie [3] sollte aber (wegen einer geringe Anzahl falsch negativer MRTs) auf die 3 Jahres Biopsie im Rahmen der aktiven Überwachung noch nicht verzichtet werden [3].…”

unclassified

Editorial

Miller¹

2020

Aktuel Urol

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Imaging in Diagnosis and Active Surveillance for Prostate Cancer

Li,

Nalavenkata,

Fainberg

2024

JAMA Surg

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ImportanceActive surveillance (AS) has become an increasingly important option for managing low-risk and select intermediate-risk prostate cancer. Although imaging, particularly multiparametric magnetic resonance imaging (mpMRI), has emerged in the prebiopsy pathway for the diagnosis of prostate cancer, the role of mpMRI in patient selection for AS and the necessity of prostate biopsies during AS remain poorly defined. Despite well-founded biopsy schedules, there has been substantial investigation into whether imaging may supplant the need for prostate biopsies during AS. This review aimed to summarize the contemporary role of imaging in the diagnosis and surveillance of prostate cancer.ObservationsMultiparametric MRI is the most established form of imaging in prostate cancer, with routine prebiopsy use being shown to help urologists distinguish between clinically significant and clinically insignificant disease. The visibility of these lesions on mpMRI closely correlates with their behavior, with visible disease portending a worse prognosis. Combined with other clinical data, risk calculators may better delineate patients with higher-risk disease and exclude them from undergoing AS. While current evidence suggests that mpMRI cannot replace the need for prostate biopsy during AS due to the possibility of missing higher-risk disease, the addition of prostate biomarkers may help to reduce the frequency of these biopsies. The role of prostate-specific antigen positron emission tomography/computed tomography is still emerging but has shown promising early results as an adjunct to mpMRI in initial diagnosis.Conclusions and RelevanceImaging in prostate cancer helps to better select patients appropriate for AS, and future studies may strengthen the predictive capabilities of risk calculators. Multiparametric MRI has been shown to be imperative to rationalizing biopsies for patients enrolled in AS. However, heterogeneity in the evidence of mpMRI during AS has suggested that further prospective studies and randomized clinical trials, particularly in homogenizing reporting standards, may reveal a more defined role in monitoring disease progression.

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The Magnetic Resonance Imaging in Active Surveillance (MRIAS) Trial: Use of Baseline Multiparametric Magnetic Resonance Imaging and Saturation Biopsy to Reduce the Frequency of Surveillance Prostate Biopsies

Cited by 54 publications

References 0 publications

Can the Use of Serial Multiparametric Magnetic Resonance Imaging During Active Surveillance of Prostate Cancer Avoid the Need for Prostate Biopsies?—A Systematic Diagnostic Test Accuracy Review

Can the Use of Serial Multiparametric Magnetic Resonance Imaging During Active Surveillance of Prostate Cancer Avoid the Need for Prostate Biopsies?—A Systematic Diagnostic Test Accuracy Review

Editorial

Imaging in Diagnosis and Active Surveillance for Prostate Cancer

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