The Magnetite Nanoparticles in Theranostic Applications

Bucharskaya, Alla B.

doi:10.15406/jnmr.2017.05.00119

Cited by 1 publication

(1 citation statement)

References 29 publications

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“…They also should have the capability to resist diverse physical and biological conditions . Among MNPs, magnetite is a relatively promising material for bioapplications because of its adequate biocompatibility, reduced toxicity, and effective magnetic characteristics and has also been authorized by the United States Food and Drug Administration (FDA). , Table displays the record of IONPs approved by the FDA and European Commission (EC) for clinical applications. Later the usage of sinerem and ferumoxide was abandoned .…”

Section: Introductionmentioning

confidence: 99%

Magnetic Nanoparticles: From Synthesis to Theranostic Applications

Khizar

Ahmad

Zine

et al. 2021

ACS Appl. Nano Mater.

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Over the past few years, engineered inorganic nanoparticles have been studied researched, and applied extensively in the biomedical field since resultant platforms increase the usage of the nanoparticles for particular theranostic applications. The innovation of such nanosystems has the potential to develop a theranostic mode that integrates both diagnosis and treatment of diseases in a particular system via combinatorial approaches of imaging, targeting, and therapy that accomplish the potential of personalized and tailored medicine. The manipulation of magnetic nanoparticles (MNPs) as theranostic agents have attained growing consideration in material science owing to their exclusive capability in magnetic targeting, magnetic resonance imaging, chemotherapy, hyperthermia, bioseparation, gene therapy, enzyme immobilization, and controlled release of the drug. To intensify the diagnostic and therapeutic efficacy, MNPs have been ornamented or functionalized with a range of materials to enhance the biocompatibility, stability, and capability to carry therapeutic payloads and to encapsulate imaging agents. Preferentially synthetic and natural polymers have been exploited to coat for ensuring their colloidal stability and good dispersibility in biological fluids. Stimuli-responsive polymers have also been used to functionalize MNPs to establish a therapeutic approach that can significantly enhance therapeutic effectiveness including the real-time monitoring in specific cells and tissues. The present review highlights the progress of MNPs emphasizing functionalization using diverse inorganic and organic and biomaterials. Furthermore, it also provides the soundproof concept on the potential of MNPs and their colloidal counterparts that offer attractive possibilities for theranostic applications. Finally, the main challenges and limitations in the use of MNPs for advanced biomedical applications have also been critically provided.

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