The main pharmacological properties  of extraction from raw material Juglans

Dayronas, Zhanna Vladimirovna; Vernikovsky, V.V.

doi:10.14300/mnnc.2019.14177

Medical news of the North Caucasus

2019

DOI: 10.14300/mnnc.2019.14177

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The main pharmacological properties of extraction from raw material Juglans

Zhanna Vladimirovna Dayronas¹,

V.V. Vernikovsky²

Abstract: Pyatigorsk medical and Pharmaceutical institute -a branch of Volgograd state medical university, russian Federationцель работы -проанализировать и систематизировать современные сведения по изучению фармакологической активности извлечений из лекарственного растительного сырья видов рода Juglans (семейство Juglandaceae). информационный поиск проводили в базах данных eLIBRARY, PubMed и Google академия. Основное внимание исследователей привлекает не только подтверждение уже известных фармакологических эффектов, но… Show more

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2022

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Features of Quantitative Estimation of Flavonoid Content in Juglans Nigra L. Barks Preparations

Куркин

Зименкина

2022

Farm. farmakol. (Pâtigorsk)

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The aim of the research is the development of quantification procedures of flavonoids in Juglans nigra L. barks preparations using modern instrumental analytical techniques (spectrophotometry, high performance liquid chromatography).Materials and methods. The subjects of research were tincture and dry extract of Juglans nigra L. bark, the samples of which were prepared in March and April 2020 in the Botanical Garden of Samara State Medical University (Samara); the standard samples (SS) of myricitrin, myricetin. The registration of the electronic spectra was carried out with a spectrophotometer «Specord 40» (Analytik Jena, Germany). The chromatographic analysis was carried out by the method of reversed-phase HPLC on a microcolumn liquid chromatograph “Milichrom-6” (NPAO “Nauchpribor”, Russia).Results. Using differential spectrophotometry, methods for the quantitative determination of the total amount of flavonoids in terms of myricitrin in the tincture and dry extract of Juglans nigra L. bark, has been developed. It has been determined that the content of the total amount of flavonoids in terms of myricitrin in the tincture and dry extract of Juglans nigra L., is 0.84±0.07% and 12.38±0.24%, respectively. The error of a single determination of the total amount of flavonoids in terms of myricitrin in the tincture and dry extract of Juglans nigra L. bark with a confidence probability of 95%, is ± 8.91% and ± 2.10%, respectively. Methods for the quantitative determination of myricitrin in the tincture and dry extract of Juglans nigra L. bark by HPLC has been developed. The content of the dominant flavonoid – myricitrin (myricetin-3-O-α-L-rhamnopyranoside) – in the tincture and dry extract of Juglans nigra L., was 0.42±0.06% and 8.45±0.24%, respectively. The error of the single determination of myricitrin in the tincture and dry extract of Juglans nigra L. with a confidence probability of 95% is ± 15.04% and ±2.96%, respectively.Conclusion. The developed methods for the quantitative determination of flavonoids in the preparations of Juglans nigra L. barks L. can be used in solving the problems of standardization of Juglans nigra L. preparations.

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Features of Quantitative Estimation of Flavonoid Content in Juglans Nigra L. Barks Preparations

Куркин

Зименкина

2022

Farm. farmakol. (Pâtigorsk)

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show abstract

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The main pharmacological properties of extraction from raw material Juglans

Cited by 1 publication

References 27 publications

Features of Quantitative Estimation of Flavonoid Content in Juglans Nigra L. Barks Preparations

Features of Quantitative Estimation of Flavonoid Content in Juglans Nigra L. Barks Preparations

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