Objective: To compare the safety and efficacy of isotonic versus hypotonic maintenance fluid in children.
Design: Randomized controlled trial.Setting: Tertiary-level teaching hospital.Participants: 60 children (age 0.5 to 12 years) who were admitted and anticipated to receive intravenous fluid for the next 48 hours.Intervention: Hypotonic fluid (Standard maintenance volume as 0.18% NaCl in 5% dextrose) or Isotonic fluid (60% Standard maintenance volume as 0.9% NaCl solution in 5% dextrose).Outcome measures: Primary: Incidence of hyponatremia. Secondary: Serum sodium, serum osmolality, blood sugar, blood urea, serum creatinine, serum potassium, serum chloride, pH, urine output, change in weight, morbidity and death. Results: At 24 hours, hyponatremia was noted in 7 (24%) patients in the isotonic and 16 (55%) in hypotonic group (P=0.031). At 48 hours, hyponatremia was noted in 4 (14%) and 13 (45%) patients in isotonic and hypotonic group, respectively (P=0.02). There was significant change in sodium levels in both isotonic (P=0.036) and hypotonic (P<0.001) intervention groups. The peak fall in mean serum sodium level was noted at 24 hours (-6.5, 95%CI: -3.5, -9.6 mEq/L; P<0.001) in hypotonic group. In isotonic group, there was significant increase between 24 and 48 hours
R R R R R E E E E E S S S S S E E E E E A A A A A R R R R R C C C C C H P H P H P H P H P A A A A A P P P P P E E E E E R R R R RR ecommendation for the use of a hypotonic saline solution (0.18% saline in 5% dextrose) in children is still a debated subject despite half a century of its practice [1]. Reports of symptomatic hyponatremia in hospitalized surgical and non-surgical pediatric patients -caused primarily by various non-osmotic release of vasopressin, but contributed by electrolyte-free water input in a proportion of cases -have fueled these debates [2][3][4][5]. Use of conventional volume maintenance isotonic saline has been shown to reduce the incidence of hyponatraemia [6]. Using indirect calorimetric measurements, energy expenditure in critically ill children may be as low as 50-60 kcal/kg/day [7]. Consequently, fluid requirement, which is directly proportional to the actual energy expenditure, is much less than previously assumed in critically ill children for a variety of reasons such as physical immobility, the use of muscle relaxants and sedatives, mechanical ventilation, and additional factors such as nonessential or facultative metabolism [8]. Therefore, we hypothesized that use of reduced volume isotonic maintenance fluid would decrease the incidence of hyponatremia in sick children, when compared to hypotonic fluid. We compared the efficacy and safety of isotonic fluid (0.9% NaCl in 5% dextrose) at the rate of 60% of daily fluid requirement versus hypotonic fluid (0.18% NaCl in 5% dextrose) at the rate of standard maintenance volume in sick children.Accompanying Editorials: Pages 963-66.