The major histocompatibility complex of primates

Heise, Eugene R.; Cook, Denys; Schepart, Brian S.; Manning, Carolina H.; McMahan, Mary Ruth; Chedid, Marcio; Keever, Carolyn A.

doi:10.1007/bf00057437

Cited by 22 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The major histocompatibility complex (MHC) is distributed in all vertebrates and is encoded by the major histocompatibility antigen gene group [ 1 ]. The concept of MHC appears to explain the phenomenon of tissue rejection and compatibility between different individuals [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Characteristics, Functional Definitions, and Regulatory Mechanisms for Cross-Presentation Mediated by the Major Histocompatibility Complex: A Comprehensive Review

Liu,

Wei,

Sun

et al. 2023

IJMS

View full text Add to dashboard Cite

The major histocompatibility complexes of vertebrates play a key role in the immune response. Antigen-presenting cells are loaded on MHC I molecules, which mainly present endogenous antigens; when MHC I presents exogenous antigens, this is called cross-presentation. The discovery of cross-presentation provides an important theoretical basis for the study of exogenous antigens. Cross-presentation is a complex process in which MHC I molecules present antigens to the cell surface to activate CD8+ T lymphocytes. The process of cross-representation includes many components, and this article briefly outlines the origins and development of MHC molecules, gene structures, functions, and their classical presentation pathways. The cross-presentation pathways of MHC I molecules, the cell lines that support cross-presentation, and the mechanisms of MHC I molecular transporting are all reviewed. After more than 40 years of research, the specific mechanism of cross-presentation is still unclear. In this paper, we summarize cross-presentation and anticipate the research and development prospects for cross-presentation.

show abstract

Section: Introductionmentioning

confidence: 99%

Molecular Characteristics, Functional Definitions, and Regulatory Mechanisms for Cross-Presentation Mediated by the Major Histocompatibility Complex: A Comprehensive Review

Liu,

Wei,

Sun

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

Swine composite tissue allotransplant model for preclinical hand transplant studies

et al. 2000

View full text Add to dashboard Cite

Reactive erosive arthritis in chimpanzees

Rothschild

Woods

1991

American J Primatol

View full text Add to dashboard Cite

Diagnosis of diseases of bone, without benefit of soft tissue, in vivo observation, or blood component analysis requires the development of new criteria for diagnosis. Analyzing chimpanzee skeletal populations, applying such criteria (e.g., lesion character, distribution, radiologic appearance, and sex ratios), revealed a picture indistinguishable from human spondyloarthropathy. As Africa has been shown to manifest this condition in indigenous human, chimpanzee, and lowland gorilla populations, the possibility of a non-species specific etiology is suggested.

show abstract

The major histocompatibility complex of primates

Cited by 22 publications

References 37 publications

Molecular Characteristics, Functional Definitions, and Regulatory Mechanisms for Cross-Presentation Mediated by the Major Histocompatibility Complex: A Comprehensive Review

Molecular Characteristics, Functional Definitions, and Regulatory Mechanisms for Cross-Presentation Mediated by the Major Histocompatibility Complex: A Comprehensive Review

Swine composite tissue allotransplant model for preclinical hand transplant studies

Reactive erosive arthritis in chimpanzees

Contact Info

Product

Resources

About