The major vault protein is dispensable for zebrafish organ regeneration

Zhang, Xue; Yang, Yanchun; Bu, Xiaoxue; Wei, Yuanyuan; Lou, Xin

doi:10.1016/j.heliyon.2020.e05422

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…In contrast, in the zebrafish CNS, axotomy-induced signals are successfully translated into a regeneration response. The upregulation of the major vault protein (mvp), constituent of the ribonucleoprotein complex, during the acute phase after SCI has been proposed as a potential regulator of cell survival under conditions of cellular stress, acting as an anti-apoptotic factor [118]. In mvp null mutant zebrafish cell death was enhanced after SCI, although little effect on axon regeneration could be observed.…”

Section: Intrinsic Regenerative Capacitymentioning

confidence: 99%

Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord

Tsata

Wehner

2021

Cells

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The capacity for long-distance axon regeneration and functional recovery after spinal cord injury is poor in mammals but remarkable in some vertebrates, including fish and salamanders. The cellular and molecular basis of this interspecies difference is beginning to emerge. This includes the identification of target cells that react to the injury and the cues directing their pro-regenerative responses. Among existing models of successful spinal cord regeneration, the zebrafish is arguably the most understood at a mechanistic level to date. Here, we review the spinal cord injury paradigms used in zebrafish, and summarize the breadth of neuron-intrinsic and -extrinsic factors that have been identified to play pivotal roles in the ability of zebrafish to regenerate central nervous system axons and recover function.

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Section: Intrinsic Regenerative Capacitymentioning

confidence: 99%

Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord

Tsata

Wehner

2021

Cells

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Transcriptomic data meta-analysis reveals common and injury model specific gene expression changes in the regenerating zebrafish heart

Botos

Arora

Chouvardas

et al. 2023

Sci Rep

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Zebrafish have the capacity to fully regenerate the heart after an injury, which lies in sharp contrast to the irreversible loss of cardiomyocytes after a myocardial infarction in humans. Transcriptomics analysis has contributed to dissect underlying signaling pathways and gene regulatory networks in the zebrafish heart regeneration process. This process has been studied in response to different types of injuries namely: ventricular resection, ventricular cryoinjury, and genetic ablation of cardiomyocytes. However, there exists no database to compare injury specific and core cardiac regeneration responses. Here, we present a meta-analysis of transcriptomic data of regenerating zebrafish hearts in response to these three injury models at 7 days post injury (7dpi). We reanalyzed 36 samples and analyzed the differentially expressed genes (DEG) followed by downstream Gene Ontology Biological Processes (GO:BP) analysis. We found that the three injury models share a common core of DEG encompassing genes involved in cell proliferation, the Wnt signaling pathway and genes that are enriched in fibroblasts. We also found injury-specific gene signatures for resection and genetic ablation, and to a lower extent the cryoinjury model. Finally, we present our data in a user-friendly web interface that displays gene expression signatures across different injury types and highlights the importance to consider injury-specific gene regulatory networks when interpreting the results related to cardiac regeneration in the zebrafish. The analysis is freely available at: https://mybinder.org/v2/gh/MercaderLabAnatomy/PUB_Botos_et_al_2022_shinyapp_binder/HEAD?urlpath=shiny/bus-dashboard/.

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The major vault protein is dispensable for zebrafish organ regeneration

Cited by 2 publications

References 29 publications

Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord

Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord

Transcriptomic data meta-analysis reveals common and injury model specific gene expression changes in the regenerating zebrafish heart

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