The Majorana Collaboration is operating an array of high purity Ge detectors to search for the neutrinoless double-beta decay of 76 Ge. The Majorana Demonstrator consists of 44.1 kg of Ge detectors (29.7 kg enriched to 88% in 76 Ge) split between two modules constructed from ultra-clean materials. Both modules are contained in a low-background shield at the Sanford Underground Research Facility in Lead, South Dakota. We present updated results on the search for neutrinoless double-beta decay in 76 Ge with 26.0 ± 0.5 kg-yr of enriched exposure. With the Demonstrator's unprecedented energy resolution of 2.53 keV FWHM at Q ββ , we observe one event in the region of interest with 0.65 events expected from the estimated background, resulting in a lower limit on the 76 Ge neutrinoless double-beta decay half-life of 2.7 × 10 25 yr (90% CL) with a median sensitivity of 4.8 × 10 25 yr (90% CL). Depending on the matrix elements used, a 90% CL upper limit on the effective Majorana neutrino mass in the range of 200-433 meV is obtained. The measured background in the low-background configurations is 11.9 ± 2.0 counts/(FWHM t yr).