This interprofessional explanatory mixed-methods research project sought to determine the impact of unanticipated deaths experienced by providers in relation to their work with persons diagnosed with a specific substance use disorder. Quantitative data were collected via the Professional Quality of Life scale, and qualitative questions were posed in an open-ended survey. The findings (N = 40) suggest that the unanticipated death of persons seeking treatment is experienced by providers as a grief response similar to disenfranchised loss, in that it affects both the provider’s sense of productivity as well as their personal self-care. The implications of this study suggest that “providers are grieving at work—about work.” As such, program administrators are encouraged to ameliorate the impact of the opioid epidemic through interprofessional integrative supports that acknowledge the impact of unanticipated deaths by providers. Future research is encouraged to better understand if the motivation for a professional initially entering this specific field mitigates the impact of unanticipated deaths.