1994
DOI: 10.1002/hep.1840200440
|View full text |Cite
|
Sign up to set email alerts
|

The Mallory Body: Morphological, Clinical and Experimental Studies (Part 1 of A Literature Survey)

Abstract: To aid understanding of markers of disease and predictors of outcome in alcohol-exposed systems, we undertook a literature survey of more than 700 articles to view the morphological characteristics and the clinical and experimental epidemiology of the Mallory body. Mallory bodies are filaments of intermediate diameter that contain intermediate filament components (e.g., cytokeratins) observable by conventional light microscopy or immunohistochemical methods, identical in structure regardless of initiating fact… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

2
58
0
5

Year Published

1998
1998
2018
2018

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 96 publications
(65 citation statements)
references
References 152 publications
2
58
0
5
Order By: Relevance
“…The presence of more pronounced steatosis in animals receiving alcohol by gavage compared to those who did not use this substance confirms the effects already described of alcohol on liver [6][7][8][9]11]. In these two groups, rare MBs (Mallory bodies) were observed, whose presence occurs in approximately 65% to 75% of cases of alcoholic hepatitis [30,31]. MBs are intracytoplasmic hyaline corpuscles that although unspecific, are primarily associated with ALD.…”
Section: Morphology Of Hepatocytessupporting
confidence: 81%
“…The presence of more pronounced steatosis in animals receiving alcohol by gavage compared to those who did not use this substance confirms the effects already described of alcohol on liver [6][7][8][9]11]. In these two groups, rare MBs (Mallory bodies) were observed, whose presence occurs in approximately 65% to 75% of cases of alcoholic hepatitis [30,31]. MBs are intracytoplasmic hyaline corpuscles that although unspecific, are primarily associated with ALD.…”
Section: Morphology Of Hepatocytessupporting
confidence: 81%
“…This suggests that additional removal of 6 amino acids may cause conformational changes that prevent COU-1 from binding. Finally, changes in the K8/K18 heterotypic network have been observed in Mallory bodies, which are characteristic cytoplasmic inclusions in hepatocytes associated with alcoholic hepatitis and other chronic hepatocellular injuries including cholestasis and various metabolic disturbances (55)(56)(57). The Mallory bodies consist predominantly of K8 and variable amounts of K18 assembled in a nonfilamentous manner as well as nonkeratin components, such as the M M 120-1 antigen and ubiquitin.…”
Section: Discussionmentioning
confidence: 99%
“…9 MDBs are characteristic of alcoholic steatohepatitis but are also found in other diseases, including nonalcoholic steatohepatitis, primary biliary cirrhosis, and Wilson disease. 9,12,13 MDBs consist mainly of the IFs keratin 8 and 18 (K8/K18) that have undergone several posttranslational modifications, including hyperphosphorylation and transamidation. 9,13 MDB formation requires an alteration in the normal equimolar K8:K18 ratio (under basal conditions) to disproportional K8ϾK18 levels that ultimately lead to K8 cross-linking and insolubility.…”
mentioning
confidence: 99%
“…9 Interestingly, DDC-primed mice (i.e., mice fed DDC long-term, then allowed to recover by feeding a normal diet) posses a remarkable ability to rapidly reform MDBs within 5 to 7 days after exposure to a variety of stress-inducing agents. 9,12 This phenomenon is referred to as "toxic memory." 14 Despite the diagnostic importance of MDBs, the precise mechanisms underlying their formation are not completely understood.…”
mentioning
confidence: 99%