The Mammary Gland

Vonderhaar, Barbara K.; Bhattacharjee, Maitreyi

doi:10.1007/978-1-4684-1236-9_6

Cited by 6 publications

(1 citation statement)

References 118 publications

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“…Such studies have shown that peptide and steroid hormones, and cell-cell and cell-substratum interactions, as well as other factors, modulate the expression of milk proteins. Milk protein genes are of interest because they provide an attractive system for studying hormonal and developmental gene regulation (Vonderhaar & Bhattacharjee, 1985) and they also have potential applications in biotechnology (Clark et al, 1987;Gordon et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

Conserved region of the rat α-lactalbumin promoter is a target site for protein binding in vitro

Luboń

Hennighausen

1988

Biochemical Journal

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Nuclear extracts from mammary glands of lactating rats contain DNA binding protein(s) with high affinity to the region -125 to -85 of the rat alpha-lactalbumin promoter. The protected sequence is part of a mammary conserved sequence described by Hall et al. [(1987) Biochem. J. 242, 735-742]. Comparison of the DNA protein-binding sites in the 5' flanking sequence of the rat alpha-lactalbumin and mouse whey acidic protein genes suggests that the consensus sequence 5'-TGGCARNNWCKKC-3' is the protein(s) recognition site. This binding site is part of a highly conserved region [consensus sequence, TGGCAGSCTCGGCST(G)YTCTCTCT(NTG)TGGCARA] present in the promoter of four whey protein genes.

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Section: Introductionmentioning

confidence: 99%

Conserved region of the rat α-lactalbumin promoter is a target site for protein binding in vitro

Luboń

Hennighausen

1988

Biochemical Journal

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Developmental regulation of the sheep β‐lactoglobulin gene in the mammary gland of transgenic mice

et al. 1991

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beta-Lactoglobulin (BLG) is the most abundant whey protein in sheep milk but it is not present in mouse milk. We have previously shown that transgenic mice carrying the BLG gene express it specifically in the mammary gland and secrete BLG into milk at high concentrations. Here we demonstrate that BLG transcription is correctly initiated in mice and that BLG synthesis is restricted to the secretory epithelial cells of the mammary gland. We have also determined the temporal pattern of milk protein gene expression and find that the BLG transgene is regulated coordinately with mouse beta-casein and that the patterns of regulation of BLG in mouse and sheep share some similarities.

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Regulation of development of the normal mammary gland by hormones and growth factors

Vonderhaar¹

1988

Cancer Treatment and Research

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The Mammary Gland

Cited by 6 publications

References 118 publications

Conserved region of the rat α-lactalbumin promoter is a target site for protein binding in vitro

Conserved region of the rat α-lactalbumin promoter is a target site for protein binding in vitro

Developmental regulation of the sheep β‐lactoglobulin gene in the mammary gland of transgenic mice

Regulation of development of the normal mammary gland by hormones and growth factors

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