The Management and Outcomes of Male Breast Cancer

Abstract

Objective: Due to a lack of sufficient data, the treatment protocols for male breast cancer are usually the same as those used for female breast cancer. The aim of the current study was to present our clinical experience with male breast cancer. Materials and Methods:The records of 37 patients who were treated for male breast cancer in our hospital between 2004 and 2014 were reviewed retrospectively. The data of patients were recorded and analyzed.Results: The mean age of the patients was 63.03±12.36 years. Thirty-three patients (89.2%) had invasive ductal carcinoma, two (5.4%) had ductal carcinoma in situ, and two had invasive lobular carcinoma (5.4%). The most common molecular subtype was luminal A (17 cases, 45.9%). Twentynine patients with male breast cancer underwent mastectomy and two underwent breast conserving surgery. Axillary lymph node dissection was performed in 25 patients. The most common surgical procedure was modified radical mastectomy. Distant metastases were present in 17 (45.9%) patients. Overall, the 5-year survival was 60%. The 5-year survival was 100% for those with stage 0-I disease, 87% for stage II, and 42% for stage III. The 3-year survival was 14% for stage IV. Conclusion:Patients with male breast cancer presented at an older age, a later stage, and with earlier metastasis. Early metastasis and death increases with increasing stage. Poor prognosis correlates with late admission. Data from different centers should be compiled and reviewed in order to determine a specific treatment protocol for male breast cancer; each paper published reveals new data.

Brain Metastasis from Breast Cancer in a Male Patient

“…The reported common sites of metastasis in male breast cancer are bones (48.78%), lungs (29.26%), liver (17.07%), spine (30%) skin and pleura. 1 Metastasis to the brain (11.8%) had been reported in the study conducted by Uslukaya et al 6 Due to the anatomy of the male breast, skin involvement is common. 4 In this case, the patient had a breast lump for a few months, but he sought treatment only after he developed seizures due to brain metastasis.…”

“…2,13 Axillary lymph node involvement is a strong predictor for the risk of local and distant recurrence. 6 The 5 years overall survival rate in negative lymph node disease is 100%, whereas the overall survival rate reduced to 79.9% in N1 disease, 66.7% in N2 and 25% in N3 disease. 3 Post-operative radiotherapy reduces the local recurrence rate.…”

“…4 Due to the absence of lobules in men, invasive lobular cancer is uncommon with an incidence of about 1%. 6 Several risk factors including genetic, hormonal, occupational and/or environmental exposure are associated with male breast cancer. 1,2,7 Nearly 15% of male breast cancers are familial with BRCA2 is the strongest.…”

Hemogram index parameters in the evaluation of male breast cancer and inflammatory response: a case-control study

“…The incidence of MBC represents less than 1% of breast cancers worldwide 1,2,8 . A mass in the breast, observed in 75-81% of patients, is the most common symptom.…”

“…The incidence of stage III/IV cancer at admission is >60% in Africa, <40% in North America and Western European countries, and between 40% and 60% in Eastern Europe and South America. The reasons for admission at later stages are reported to be race, low socioeconomic status, lack of awareness about the disease, and uncertainties in the characterization of highrisk patients for screening in the literature 8,[11][12][13][14][15][16][17] . In our study, the most common symptom was a breast mass, and 50% of them were at late stages at the time of diagnosis.…”