1989
DOI: 10.1007/bf03259901
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The Management of Acute Poisoning Due to β-Adrenoceptor Antagonists

Abstract: Although many cases of beta-adrenoceptor antagonist (beta-blocker) poisoning are uneventful, a proportion develop serious and sometimes fatal cardiovascular system depression with severe hypotension. As beta-adrenergic tone is not essential for cardiovascular function in health, there is no physiological reason why total beta-adrenoceptor blockade should have serious consequences in the resting individual. The toxic actions of beta-blockers appear to be related to properties such as membrane depressant activit… Show more

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Cited by 25 publications
(1 citation statement)
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“…[45] BBs with low lipid solubility that lack membrane stabilizing effects are safer so also the newer CCBs than the diltiazem and verapamil. [1678] The lowest reported toxic doses of common BBs and CCBs were reported recently. The lowest reported toxic dose of atenolol in for an adult was 500 mg and amlodipine was 30 mg.[9]…”
Section: Discussionmentioning
confidence: 99%
“…[45] BBs with low lipid solubility that lack membrane stabilizing effects are safer so also the newer CCBs than the diltiazem and verapamil. [1678] The lowest reported toxic doses of common BBs and CCBs were reported recently. The lowest reported toxic dose of atenolol in for an adult was 500 mg and amlodipine was 30 mg.[9]…”
Section: Discussionmentioning
confidence: 99%