The management of chemical pleurodesis with viscum album in patients with persistent air leakage

Park, Jae Bum; Lee, Song Am; Lee, Woo Surng; Kim, Yo Han; Hwang, Jae Joon

doi:10.21037/jtd.2017.12.67

Cited by 8 publications

(11 citation statements)

References 25 publications

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“…Numerous drugs such as talc, iodopovidone, doxycycline, minocycline, bleomycin, autologous blood, and OK432 have been used to treat seromas or malignant pleural effusion. Although the most effective drug remains to be identified, V. album extract is a newly introduced chemical agent that has been extensively studied given its low risk of adverse reactions and good therapeutic effects [8]. One of the ingredients of V. album extract is viscumin, which is intensely toxic.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it aids in eliminating dead space through immune responses that stimulate the synthesis of macrophage colony-stimulating factors and increase the concentrations of interferon, interleukins, tumor necrosis factors, and natural killer cells [9]. Treatments using V. album extract have been reported to lead to mild adverse events such as local heat sensations and local pain, which tend to resolve shortly afterward [7,8]. In fact, one of our patients experienced a local heat following V. album extract injection, which had improved by the next day without systemic fever or other complications.…”

Section: Discussionmentioning

confidence: 99%

“…Viscum alhttps://doi.org/10.22467/jwmr.2021.01837 bum extract is a drug used to treat malignant pleural effusion during pleurodesis. Its safety and efficacy as a sclerosing agent have been confirmed by several studies [7,8]. Furthermore, several reports have described the successful treatment of seromas in the flap donor site using V. album extract [9].…”

Section: Introductionmentioning

confidence: 85%

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Treatment for a Post-Reconstruction Seroma Using Viscum album Extract in a Patient with a Pressure Ulcer: A Case Series

Hwang

Choi

et al. 2022

J Wound Manag Res

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Seromas commonly occur or recur after reconstructive surgery in patients with pressure ulcers, often leading to infection, increasing the risk of wound dehiscence and flap necrosis, and therefore requiring an additional surgical procedure. Various strategies have been employed to treat seroma, such as retaining as much of the fascia as possible, using progressive tension sutures, inserting suction drains, utilizing sclerotherapy, or applying compression via dressings or specialized garments. However, despite these efforts, seroma prevention remains difficult. In the current report, we describe three cases in which we administered Viscum album extract to prevent and treat seromas that developed following pressure ulcer reconstruction. V. album extract sclerotherapy was performed in a patient with a recurrent seroma, a patient with a persistent seroma, and a patient wishing to undergo sclerotherapy immediately postoperatively as a prophylactic treatment. The seromas resolved shortly after initiating treatment, and recurrence was not observed at any of the subsequent outpatient follow-up visits. These cases suggest that sclerotherapy with V. album extract following pressure ulcer reconstruction can suppress development of seromas and lower the risk of recurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 85%

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Treatment for a Post-Reconstruction Seroma Using Viscum album Extract in a Patient with a Pressure Ulcer: A Case Series

Hwang

Choi

et al. 2022

J Wound Manag Res

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“…One of the most important issues in the treatment of PSP is preventing recurrence. Although surgery is the most effective treatment for PSP, the recurrence rate of pneumothorax remains 5-15% after thoracoscopic surgery [3][4][5][6]11,12 . In order to minimize recurrence rate of postoperative pneumothorax, chemical pleurodesis has been performed simultaneously with resection or sequentially.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Viscum Pleurodesis and Bullectomy in Patients With Primary Spontaneous Pneumothorax

Jung

Kim

2021

Preprint

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Objectives: Although surgery is the gold standard for treatment of primary spontaneous pneumothorax (PSP), recurrence after surgery remains a concern. This study sought to evaluate the efficacy of simultaneous pleurodesis using Viscum album (VA) extract and bullectomy for the treatment of PSP.Methods: From March 2016 to November 2020, 196 patients with PSP underwent bullectomy and intraoperative pleurodesis with VA extract at a single institution. All operations were performed through video-assisted thoracic surgery by one surgeon. Upon completion of bullectomy, a polyglycolic acid sheet was used to cover the stapler lines, and 40 mg of VA extract was instilled over the entire chest wall before chest tube placement.Results: The mean operating time was 18.5±5.0 minutes (range, 10–65) and the mean indwelling time of chest drainage was 1.8±0.5 days (range, 2–6). There were no postoperative complications over grade 3. During the median follow-up period of 36.3±18.4 months (range, 2–57), no recurrence of pneumothorax was observed.Conclusions: The results of this study demonstrated that simultaneous Viscum pleurodesis and bullectomy provides a feasible and effective treatment option for preventing postoperative pneumothorax in patients with PSP.

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“…Therefore, interest has emerged in methods of whole-capsule sclerotherapy for use before considering surgical methods. In the field of thoracic surgery, Abnobaviscum is used to treat adhesions in cases of malignant pleural effusion, and an attempt has been made to use this product to treat seroma [6]. Some studies have reported Abnobaviscum to be effective against malignant pleural effusion, and its efficacy as a sclerosing agent has also been recognized [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Use of Abnobaviscum to treat refractory seroma after breast reconstruction with a latissimus dorsi flap: A case report

Kim

Lee

et al. 2019

Arch Aesthetic Plast Surg

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In recent years, there has been a notable increase in the rate of refractory donor site seroma, defined as seroma that persists for at least 3 months postoperatively, as the number of breast reconstructions using a latissimus dorsi (LD) musculocutaneous flap has increased. Various factors have been proposed to be related, including smoking, obesity, flap mass, and body weight, and several studies have been conducted to explore treatment methods. Typically, surgical treatment, such as capsulectomy, has been considered for refractory seroma, but in this case report, we describe positive outcomes achieved by using Abnobaviscum to treat three female patients who developed a donor site seroma at least 3 months after breast reconstruction using an LD flap.

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The management of chemical pleurodesis with viscum album in patients with persistent air leakage

Abstract: Air leaks remain an important cause of morbidity. This viscum album pleurodesis could be considered as an option for the treatment of prolonged air leak patients, associated with acceptable side effects.

Cited by 8 publications

References 25 publications

Treatment for a Post-Reconstruction Seroma Using Viscum album Extract in a Patient with a Pressure Ulcer: A Case Series

Treatment for a Post-Reconstruction Seroma Using Viscum album Extract in a Patient with a Pressure Ulcer: A Case Series

Simultaneous Viscum Pleurodesis and Bullectomy in Patients With Primary Spontaneous Pneumothorax

Use of Abnobaviscum to treat refractory seroma after breast reconstruction with a latissimus dorsi flap: A case report

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