The Management of Hemoglobinuria in Extensive Burns

Dudley, Haf; Batchelor, A.D.R.; Sutherland, Alistair

doi:10.1097/00006534-195706000-00020

Cited by 3 publications

(2 citation statements)

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“…Where treatment has been prompt a rapid response can be expected. The urine output climbs sharply and serial specimens show progressive disappearance of pigment (Dudley, Batchelor and Sutherland, 1957).…”

Section: Renal Damagementioning

confidence: 99%

The Resuscitation of Burned Children

Batchelor¹

1957

Archives of Disease in Childhood

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Section: Renal Damagementioning

confidence: 99%

The Resuscitation of Burned Children

Batchelor¹

1957

Archives of Disease in Childhood

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“…Accordingly, recommended preventive measures have included adequate resuscitation, hydration with diuresis, and alkali therapy. In particular, hydration and osmotic diuresis (e.g., as induced by infu sion of hypertonic mannitol) have been recommended to reduce or virtually to eliminate the risk of acute renal failure in such situations as crush injury (14), hemolytic transfusion reaction (8,24), elective surgery including aortic resection (4,6,12,36), extracorporeal circula tion (23), and accidental trauma (9,16). Other agents have also been recommended (3,35), and both the necessity and the safety of osmotic diuresis has been questioned (10,21,22,39,40,47).…”

Section: Introductionmentioning

confidence: 99%

Studies in Acute Renal Failure

Teschan

Lawson²

1966

Nephron

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In a previously documented experimental model of acute renal failure in the rat (intravenous methemoglobin-ferrocyanide) 1 ml doses of 25% mannitol (1.21–1.54 g/kg) intravenously prevented both functional and histologic renal injury within –1 h and +30 min of attempted induction. When varying mannitol doses were given 15 min following attempted induction, a sigmoid log-log relationship of plasma urea nitrogen (PUN) concentration to mannitol dose was demonstrated. Mannitol doses above 300 mg/kg (at + 15 min) are estimated to be fully protective in the model. Similarly at 15 min following attempted induction, isosmolal 1 ml doses of aqueous mannitol, mannose, sucrose, sodium sulfate, sodium chloride, THAM [tris(hydroxymethyl)aminomethane] and thriceisosmolal urea prevented acute renal failure, but isosmolal urea and dextrose, isotonic saline and 6% human serum albumin did not. Both 6% dextran (av. mol. wt. 75,000) and 10% dextran (av. mol. wt. 40,000) intensified the lesions, possibly a unique reaction in the rat. Effective agents induced higher rates of urinary flow in anesthetized, normal rats than ineffective ones. The results indicate that, in this model, (a) several osmotic diuretic agents are capable of preventing acute renal failure; (b) preventive effectiveness correlates with the ability of an agent to induce prompt, brisk diuresis; (c) the preventive therapy must be timely to be effective; and (d) the probable protective mechanism is that the agent augments the pathogenetically-significant, reduced renal tubular fluid flow. The results also imply that the protective mechanism does not depend upon extracellular or plasma volume expansion, relief of renal ischemia, osmotic loading per se, or a specific chemical or pharmacological characteristic of any single agent.

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Delayed death in burns and the allegations of medical negligence

Sharma

2006

Burns

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The Management of Hemoglobinuria in Extensive Burns

Cited by 3 publications

References 0 publications

The Resuscitation of Burned Children

The Resuscitation of Burned Children

Studies in Acute Renal Failure

Delayed death in burns and the allegations of medical negligence

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