The management of hidradenitis suppurativa degenerating into squamous cell carcinoma: About three case reports

Atri, Souhaib; Mahmoud, Ahmed Ben; Zehani, Alia; Chammakhi, Amine; Rebai, Wael; Kacem, Montasser

doi:10.1016/j.amsu.2021.102239

Cited by 3 publications

References 11 publications

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A state-of-the-art systematic review of cancer in hidradenitis suppurativa

Abu Rached,

Rüth,

Gambichler

et al. 2024

Annals of Medicine

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Purpose Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with an increased risk of malignancy. The aim of this systematic review was to investigate the prevalence of different malignancies in HS. Methods This review meets the PRISMA criteria. A data-driven approach was used to conduct the research, which involved a detailed keyword search. The study considered meta-analyses, experimental studies, case-control studies, cross-sectional studies, cohort studies, and recently published cases, published in English or German. Excluded were reviews, summaries, and letters to the editor, as well as studies, which are not based on the human population. Results Out of the initial 443 publications found, 25 met the inclusion criteria for this systematic review. Patients with HS have a significantly increased risk of cancer, up to 50%. Additionally, the risk of oropharyngeal, central nervous system, colorectal, prostate, vulvar and non-melanocytic skin cancers increase with the severity of HS. The likelihood of comorbid lymphoma in patients with HS is significantly higher compared to healthy controls. In severe cases of HS, malignant degeneration of lesions in the groin, perianal, perineal, and gluteal region can occur in up to 4.6% of cases. This leads to the development of cSCC, which often have a complicated course, are more refractory to treatment and associated with a poorer outcome. The pathogenic mechanisms responsible for the malignant transformation of HS are currently unknown. Conclusions Patients with HS have a higher risk of cancer compared to the general population. Untreated, long-standing HS lesions can lead to complicated malignant degeneration resulting in cutaneous squamous cell carcinoma. The mechanisms underlying this malignant degeneration are not fully understood. HS patients also have an increased risk of developing other cancers, including prostate, oral, pharyngeal and colorectal cancers of the central nervous system and lymphomas.

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A state-of-the-art systematic review of cancer in hidradenitis suppurativa

Abu Rached,

Rüth,

Gambichler

et al. 2024

Annals of Medicine

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Hidradenitis suppurativa and squamous cell carcinoma: a systemic review of the literature

Gierek¹,

Niemiec²,

Szyluk³

et al. 2023

pdia

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Hidradenitis suppurativa (HS) is a chronic disease which is often recurrent and occurs as abscesses of the apocrine gland. The most common locations of HS are gluteal/perianal, axillary or inguinal. It is reasonable to assume that squamous cell carcinoma may arise from HS. As researchers in the field of dermatology, HS surgery and conventional surgical oncology, we studied whether there is any correlation between HS and neoplasms. Evidence shows a correlation between HS and squamous cell carcinoma. The aim of the study was to find literature about HS and SCC and analyse potential risk factors. This is a systemic review concerning squamous cell carcinoma and hidradenitis suppurativa.

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Hidradenitis Suppurativa

Hazany,

Zhou,

Bronte

et al. 2024

Dermatology - The Latest Research on the Most Common Diseases [Working Title]

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Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disorder characterized by painful nodules, abscesses, and tunneled sinus tract formation, predominantly affecting areas rich in apocrine glands. The disease poses significant diagnostic and therapeutic challenges due to its complex pathophysiology and variable clinical presentations. Early detection and intervention are critical in preventing disease progression and minimizing its impact on patients’ quality of life. This chapter provides an overview of HS, including diagnostic approaches and management strategies, with a particular focus on surgical interventions. Wide local excision remains the gold standard for achieving long-term remission, but tissue-sparing techniques like deroofing offer effective alternatives, particularly in cases where post-procedural complications or cosmetic concerns are paramount. The role of advanced imaging modalities, such as ultrasound, is also discussed, emphasizing their utility in accurately assessing disease extent and guiding surgical decisions. Through a detailed case study, we highlight the importance of ultrasound guidance in identifying hidden disease processes that may elude conventional clinical evaluation. This chapter aims to provide clinicians with a comprehensive understanding of HS, promoting informed decision-making and improved patient outcomes.

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The management of hidradenitis suppurativa degenerating into squamous cell carcinoma: About three case reports

Cited by 3 publications

References 11 publications

A state-of-the-art systematic review of cancer in hidradenitis suppurativa

A state-of-the-art systematic review of cancer in hidradenitis suppurativa

Hidradenitis suppurativa and squamous cell carcinoma: a systemic review of the literature

Hidradenitis Suppurativa

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