The management of interstitial cystitis: an update

Phatak, Sagar; Foster, Harris E.

doi:10.1038/ncpuro0385

Cited by 44 publications

(34 citation statements)

References 56 publications

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“…Tricyclic antidepressants, such as amitriptyline, may increase bladder capacity through β-adrenoceptors on the bladder and inhibition of the hypersensitivity of the bladder sensory nerves by blocking reuptake of noradrenalin and serotonin, as well as anticholinergic and antihistaminic effects (7,50,51). The anti-inflammatory effect of NSAIDs, such as indomethacin, helps to reduce the hypersensitivity of the bladder sensory nerves (52,53), although the anti-inflammatory effect on the bladder inflammation, which was indicated by increased bladder weight and induction of TNF-α mRNA expression, was not observed in the present administration schedule. A potent opioid analgesic, morphine, may be used for severe bladder pain and referred pain in IC patients (34), while it suppresses urinary frequency through spinal and supraspinal mechanisms by acting on μ-opioid receptors (54,55).…”

Section: Discussionmentioning

confidence: 99%

A Novel Mouse Model of Chronic Inflammatory and Overactive Bladder by a Single Intravesical Injection of Hydrogen Peroxide

et al. 2013

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Section: Discussionmentioning

confidence: 99%

A Novel Mouse Model of Chronic Inflammatory and Overactive Bladder by a Single Intravesical Injection of Hydrogen Peroxide

et al. 2013

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“…PBS/IC is a debilitating chronic disease characterized by suprapubic pain related to bladder filling, coupled with urinary frequency, without proven urinary infection or other obvious pathology (8,16,41,60). While the etiology is unknown, theories explaining the pathophysiology of PBS/IC include an altered urothelial barrier, neurogenic inflammation including mast cell infiltration and afferent sensitization (6,7,36,61).…”

Section: Discussionmentioning

confidence: 99%

Bladder hyperactivity and increased excitability of bladder afferent neurons associated with reduced expression of Kv1.4 α-subunit in rats with cystitis

Hayashi

Takimoto²,

Chancellor³

et al. 2009

American Journal of Physiology-Regulatory, Integrative and Comp

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Hayashi Y, Takimoto K, Chancellor MB, Erickson KA, Erickson VL, Kirimoto T, Nakano K, de Groat WC, Yoshimura N. Bladder hyperactivity and increased excitability of bladder afferent neurons associated with reduced expression of Kv1.4 ␣-subunit in rats with cystitis. Am J Physiol Regul Integr Comp Physiol 296: R1661-R1670, 2009. First published March 11, 2009 doi:10.1152/ajpregu.91054.2008.-Hyperexcitability of C-fiber bladder afferent pathways has been proposed to contribute to urinary frequency and bladder pain in chronic bladder inflammation including interstitial cystitis. However, the detailed mechanisms inducing afferent hyperexcitability after bladder inflammation are not fully understood. Thus, we investigated changes in the properties of bladder afferent neurons in rats with bladder inflammation induced by intravesical application of hydrochloric acid. Eight days after the treatment, bladder function and bladder sensation were analyzed using cystometry and an electrodiagnostic device of sensory function (Neurometer), respectively. Whole cell patch-clamp recordings and immunohistochemical staining were also performed in dissociated bladder afferent neurons identified by a retrograde tracing dye, Fast Blue, injected into the bladder wall. Cystitis rats showed urinary frequency that was inhibited by pretreatment with capsaicin and bladder hyperalgesia mediated by C-fibers. Capsaicin-sensitive bladder afferent neurons from sham rats exhibited high thresholds for spike activation and a phasic firing pattern, whereas those from cystitis rats showed lower thresholds for spike activation and a tonic firing pattern. Transient A-type K ϩ current density in capsaicinsensitive bladder afferent neurons was significantly smaller in cystitis rats than in sham rats, although sustained delayed-rectifier K ϩ current density was not altered after cystitis. The expression of voltage-gated K ϩ Kv1.4 ␣-subunits, which can form A-type K ϩ channels, was reduced in bladder afferent neurons from cystitis rats. These data suggest that bladder inflammation increases bladder afferent neuron excitability by decreasing expression of Kv1.4 ␣-subunits. Similar changes in capsaicin-sensitive C-fiber afferent terminals may contribute to bladder hyperactivity and hyperalgesia due to acid-induced bladder inflammation. urinary bladder; hyperalgesia; inflammation; C-fiber afferent; potassium channel IT HAS BEEN DEMONSTRATED THAT afferent pathways innervating the urinary bladder consist of myelinated A␦-fibers and unmyelinated C-fibers and that hyperexcitability of C-fibers in bladder afferent pathways contributes to bladder overactivity and/or bladder pain under pathological conditions such as painful bladder syndrome/interstitial cystitis (PBS/IC) (60, 61).Voltage-gated K ϩ (Kv) currents are major determinants of neuronal excitability. Kv currents in sensory neurons are divided into two major categories; i.e., sustained delayed rectifier-type K ϩ (K DR ) and transient A-type K ϩ (K A ) currents (19,21,30,57). K A currents in sensory neurons ...

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“…[1][2][3][4] The primary symptoms of IC include pelvic or perineal pain, urinary urgency and frequency, and nocturia. 5,6 Recent epidemiological research indicates that IC is very common and may affect as many as 20% of women.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for poor sleep quality among patients with interstitial cystitis in Taiwan

Tsai

Ouyang

Tsai

et al. 2009

Neurourology and Urodynamics

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The management of interstitial cystitis: an update

Cited by 44 publications

References 56 publications

A Novel Mouse Model of Chronic Inflammatory and Overactive Bladder by a Single Intravesical Injection of Hydrogen Peroxide

A Novel Mouse Model of Chronic Inflammatory and Overactive Bladder by a Single Intravesical Injection of Hydrogen Peroxide

Bladder hyperactivity and increased excitability of bladder afferent neurons associated with reduced expression of Kv1.4 α-subunit in rats with cystitis

Risk factors for poor sleep quality among patients with interstitial cystitis in Taiwan

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