The Management of Leukæmia in Pregnancy

Galton, D. J.

doi:10.1177/003591576205500906

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…The optimal treatment of patients with chronic myeloid leukaemia in the chronic phase remains controversial but there is no compelling reason for treating asymptomatic patients, who typically have blood counts < 100 x 109/1 (Goldman 1986a). Indeed early reports by Moloney (1964) and Galton (1962) suggested that patients could safely be managed without specific treatment in pregnancy. The four patients reported here did receive treatment, either leucapheresis or leucapheresis combined with cytotoxic drugs, but such treatment did not appear to affect adversely either the mother or the fetus.…”

Section: Discussionmentioning

confidence: 99%

Management of chronic myeloid leukaemia in pregnancy

Arthur

Mijović

Dannie

et al. 1991

Journal of Obstetrics and Gynaecology

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We studied six pregnancies occurring in four patients with chronic myeloid leukaemia, diagnosed before pregnancy in one case and during the first pregnancy in three cases. For one patient the first pregnancy ended in spontaneous abortion but a second pregnancy, during which she was treated only by leucapheresis, was essentially uneventful although the baby was born with spina bifida and a small meningomyelocele and talipes. A second patient delivered a normal baby after treatment by leucapheresis alone during pregnancy. A third patient was treated with hydroxyurea from 16 weeks in her first pregnancy and with leucapheresis and hydroxyurea during the second pregnancy. Both babies were normal. A fourth patient was treated with busulphan in the third trimester of pregnancy and subsequently by leucapheresis immediately before delivery of a normal baby. Pregnancy may proceed normally in patients with chronic myeloid leukaemia; leucapheresis may be advisable in the first or second trimester but cytotoxic drugs can usually be administered in the later stages of pregnancy without undue risk to the fetus.

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Section: Discussionmentioning

confidence: 99%

Management of chronic myeloid leukaemia in pregnancy

Arthur

Mijović

Dannie

et al. 1991

Journal of Obstetrics and Gynaecology

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Pregnancy in Leukaemia

Stevens

Fisher

1965

Aust NZ J Obst Gynaeco

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THE association of pregnancy and acute leukaemia is rare. In 1943 McGoldrick and Lapp collected 34 such cases which had been recorded in the world literature. Yahia, Hyman and Phillips (1958) found reports of an additional 32'cases between 1943 and 1956. In most instances an acute onset of the leukaemia was observed during the course of an established pregnancy. Premature labour was common; the foetal mortality in the earlier reported group was 60%, whilst in the latter group it was below 40%. None of the babies developed leukaemia so far as is known. Although all mothers died during the pregnancy or within a few months post partum, survival time should improve in future with modern treatment.

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Management of Leukemia in Pregnancy

Moloney

1964

Annals of the New York Academy of Sciences

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The Management of Leukæmia in Pregnancy

Cited by 4 publications

References 20 publications

Management of chronic myeloid leukaemia in pregnancy

Management of chronic myeloid leukaemia in pregnancy

Pregnancy in Leukaemia

Management of Leukemia in Pregnancy

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