The Management of Pigmented Nevi and Malignant Melanomas

Primary Malignant Melanoma of the Vagina

“…Compared to cutaneous melanoma, the frequency of primary vaginal melanoma is probably no higher than 0.3% [6,20,21]. In 1948, Mino et al [15] reported one case and found 17 others in the literature as far back as 1887.…”

MELANOMA1

“…Metastases occur most often in the lungs and liver, then in the heart and stomach according to Pack (1948). Allen and Spitz (1954) and Miescher (1955) found that tumours arising in the vicinity of a malignant lesion are often melanocytomas turned maligneuit and not met«kstases.…”

Malignant Melanoma of the Skin: Report of 341 Cases Treated during the Years 1929-1943

“…Melanomas of the extremities will have to be treated by amputation (cfr. 52,53,55). These more radical interventions have to be tried and evaluated.…”

“…Why should not similar good results be obtained in patients with malignant melanoma? -PACK stated in 1947 (55), that by applying such ivide local excisions of the primary melanomas plus regional gland dissection »in continuity», the cure rate was increased by 600 per cent in comparison with the cure rate previously gained by conservative surgery in combination with radiation. A detailed report of end-results in melanoma is consequently expected from the Memorial Hospital.…”

“…More patients will evidently be salvaged by too wide excisions than by inadequate or repeated operations. We hope that in suitable cases ex cision and dissection »in continuity» for melanoma, as advocated by the Memorial Hospital Group (52)(53)(54)(55)(56), and further the »prophylactic» dissection of regional glands (1,9,25,28,33,34,45,(52)(53)(54)66) will provide more cures than previously used methods have given.…”