The Management of Staphylococcal Toxic Shock Syndrome. A Case Report

Bîrluțiu, Victoria; Criştiu, Ofelia; Baicu, Marius; Bîrluţiu, Rareş Mircea

doi:10.1515/jccm-2016-0011

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Several studies indicate the perineal presence of Staphylococcus aureus in over 90% of women with Staphylococcal Toxic Shock Syndrome [22,23]. The initial signs and symptoms can sometimes misguide the physician into establishing a diagnosis of alergodermia and initiating treatment with corticosteroids [24]. The patient in the present case was also treated initially with corticosteroids, the condition being mistaken for acute generalized exanthema pustulosis.…”

Section: Discussionmentioning

confidence: 70%

Staphylococcal Scalded Skin Syndrome in Child. A Case Report and a Review from Literature

Grama

Mărginean

Meliţ

et al. 2016

The Journal of Critical Care Medicine

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Staphylococcal scalded skin syndrome (SSSS) is the medical term used to define a skin condition induced by the exfoliative toxins produced by Staphylococcus aureus. The disorder is also known as Ritter disease, bullous impetigo, neonatal pemphigus, or staphylococcal scarlet fever. The disease especially affects infants and small children, but has also been described in adults. Prompt therapy with proper antibiotics and supportive treatment has led to a decrease in the mortality rate. The current case report describes the clinical progress of a patient with generalized erythema and fever, followed by the appearance of bullous lesions with tendency to rupture under the smallest pressure, and with extended areas of denudation. The patient aged four years and six months was admitted to our clinic to establish the aetiology and treatment of a generalized bullous exanthema, followed by a skin denudation associated with fever and impaired general status. Based on clinical and paraclinical examinations a diagnosis of Staphylococcal scalded skin syndrome was established which responded favourably to antibiotic treatment, hydro-electrolytic re-equilibration, and adequate local hygiene. Staphylococcal infection can represent a problem of significant pathological importance sometimes requiring a multidisciplinary approach involving paediatricians, dermatologists, infectious diseases specialists, and plastic surgeons.

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Section: Discussionmentioning

confidence: 70%

Staphylococcal Scalded Skin Syndrome in Child. A Case Report and a Review from Literature

Grama

Mărginean

Meliţ

et al. 2016

The Journal of Critical Care Medicine

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“…Within the family of staphylococcal enterotoxins (SEs), in addition to SEB, toxic shock syndrome toxin 1 (TSST-1) is included, and it has been reported to be highly associated with SEB cases [22]. Staphylococcal toxic shock syndrome (TSS) has a mortality rate of 50-60%, depending on the severity of the clinical case [23].…”

Section: Discussionmentioning

confidence: 99%

The SEB1741 Aptamer Is an Efficient Tool for Blocking CD4+ T Cell Activation Induced by Staphylococcal Enterotoxin B

et al. 2023

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Staphylococcal enterotoxin B (SEB) is a protein produced by Staphylococcus aureus, which is toxic to humans. It is well known for its ability to stimulate the exacerbated activation of proinflammatory CD4+ T cells (Th1 profile), and in vitro studies have been conducted to understand its mechanism of action and its potential use as an immune therapy. However, the efficiency of the SEB1741 aptamer in blocking SEB has not been experimentally demonstrated. Methods: Enrichment CD4+ T cells were stimulated with SEB, and as a blocker, we used the SEB1741 aptamer, which was previously synthesised by an “in silico” analysis, showing high affinity and specificity to SEB. The efficiency of the SEB1741 aptamer in blocking CD4+ T cell activation was compared with that of an anti-SEB monoclonal antibody. Flow cytometry and Bio-Plex were used to evaluate the T-cell function. Results: In vitro, SEB induced the activation of CD4+ T cells and favoured a Th1 profile; however, the SEB1741 aptamer was highly efficient in decreasing the frequency of CD4+ T cells positive to ki-67 and CD69 cells, this means that proliferation and activation of CD4+ T cells was decreased. Moreover, the production of interleukin 2 (IL-2) and interferon-gamma (IFN-γ) was affected, suggesting that the Th1 profile is not present when the SEB1441 aptamer is used. Thus, the SEB1741 function was similar to that of anti-SEB. Conclusions: The SEB1741 aptamer is a valuable tool for blocking CD4+ T cell activation and the subsequent release of proinflammatory cytokines by SEB stimulation.

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“…4 S. aureus can produce toxic shock syndrome toxin-1, staphylococcal enterotoxin B, and other exotoxins. 5 These exotoxins are referred to as superantigens because of their potential for polyclonal activation of T cells. Activated T cells release large amounts of cytokines that cause a large variety of clinical symptoms.…”

Section: Discussionmentioning

confidence: 99%

Staphylococcal Toxic Shock Syndrome after Autologous Breast Reconstruction: A Case Report and Literature Review

Nakamura

Makiguchi

Hasegawa

et al. 2022

Plastic and Reconstructive Surgery - Global Open

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Summary: Staphylococcal toxic shock syndrome (TSS) is a rare but potentially life-threatening systemic bacterial intoxication. TSS is characterized by fever, hypotension, rash, digestive symptoms such as vomiting and diarrhea, multiorgan system involvement, and desquamation in the initial recovery period. We report a case of a 35-year-old woman who developed TSS caused by methicillin-resistant Staphylococcus aureus following deep inferior epigastric perforator flap breast reconstruction. Local findings are often not obvious in a case of TSS, which can make early diagnosis and appropriate initial treatment difficult. If a patient presents with characteristic symptoms of TSS after autologous breast reconstruction, TSS should be suspected and exploration of surgical wounds should be initiated as soon as possible.

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The Management of Staphylococcal Toxic Shock Syndrome. A Case Report

Cited by 3 publications

References 12 publications

Staphylococcal Scalded Skin Syndrome in Child. A Case Report and a Review from Literature

Staphylococcal Scalded Skin Syndrome in Child. A Case Report and a Review from Literature

The SEB1741 Aptamer Is an Efficient Tool for Blocking CD4+ T Cell Activation Induced by Staphylococcal Enterotoxin B

Staphylococcal Toxic Shock Syndrome after Autologous Breast Reconstruction: A Case Report and Literature Review

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