“…This category is referred to as "red flag" covers 1) previous history of malignancy-could indicate new primary, recurrence, or metastases; 2) persistent or unexplained neck lump or cervical lymphadenopathy-may indicate a neoplastic, infective, or autoimmune cause; 3) neurological symptoms, for example, headache or cranial nerve abnormalities with sensory or motor function changemay indicate an intracranial cause, or malignancy affecting cranial nerve peripheral branches; 4) facial asymmetry, facial swelling, or profound trismus-may indicate a neoplastic, infective, or inflammatory cause; 5) recurrent epistaxis, purulent nasal discharge, persistent anosmia, or reduced hearing on the ipsilateral side-may indicate nasopharyngeal carcinoma; 6) unexplained fever or weight loss-may indicate malignancy, immunosuppression, or other infective causes, for example, septic arthritis; 7) new-onset unilateral headache or scalp tenderness, jaw claudication, and general malaise, if the person is more than 50 years of age-may indicate giant cell arteritis; and 8) occlusal changes-may indicate neoplasia rheumatoid arthritis, trauma, or bone growth around the TMJ, for example, acromegaly. 1 Signs and symptoms categorized into "red flag" need to be considered and if found, they must be all the way to refer to more competent practitioners. It must be noted that these red flag symptoms in isolation should prompt their own line of enquiry and management.…”