The management of treatment-related esophageal complications in children and adolescents with cancer

Lal, Dave R.; Foroutan, Hamid Reza; Su, Wendy; Wolden, Suzanne L.; Boulad, Farid; Quaglia, Michael P. La

doi:10.1016/j.jpedsurg.2005.11.065

Cited by 30 publications

(14 citation statements)

References 16 publications

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“…Barium swallow, which is used in patients treated for head and neck cancer to assess the safety of oral feeding and the structural integrity of the pharynx and oesophagus [10], has not been employed for HSCT recipients, and the use of endoscopic optical coherence tomography in combination with Doppler capability may augment imaging of the mucosal and submucosal structures of the oesophagus but is only feasible for patients given less intensive chemo-/radiotherapy [12]. These techniques could be used to investigate the late post-chemotherapy complications like fistulae, which tend to occur after anti-leukaemic treatment [7]. Hence, another clinical tool needs to be developed, one that is easy and relatively safe to use and does not involve endoscopy.…”

Section: Discussionmentioning

confidence: 99%

Determining mucosal barrier injury to the oesophagus using CT scan

Blijlevens

Donnelly

Yakar

et al. 2007

Support Care Cancer

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Section: Discussionmentioning

confidence: 99%

Determining mucosal barrier injury to the oesophagus using CT scan

Blijlevens

Donnelly

Yakar

et al. 2007

Support Care Cancer

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“…70;71 Additional risk factors for esophageal stricture specifically include chronic GVHD, prior candida esophagitis, and gastroesophageal reflux. 70;72 Late bowel obstruction can be seen many years after abdominal surgery. 70;72 …”

Section: Gastrointestinalmentioning

confidence: 99%

Late Effects Surveillance Recommendations among Survivors of Childhood Hematopoietic Cell Transplantation: A Children's Oncology Group Report

Chow

Anderson

Baker

et al. 2016

Biology of Blood and Marrow Transplantation

180

152

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Hematopoietic cell transplantation (HCT) is an important curative treatment for children with high-risk hematologic malignancies and solid tumors, and increasingly, non-malignant diseases. Given improvements in care, there is a growing number of long-term survivors of pediatric HCT. Compared with non-transplanted childhood cancer survivors, HCT survivors have been shown to have a substantially increased burden of serious chronic conditions and impairments involving virtually every organ system and overall quality of life. This likely reflects the joint contributions of pre-transplant treatment exposures and organ dysfunction, the transplant conditioning regimen, and any post-transplant graft versus host disease (GVHD). In response, the Children’s Oncology Group (COG) has created Long-Term Follow-Up Guidelines (www.survivorshipguidelines.org) for survivors of childhood, adolescent, and young adult cancer, including those treated with HCT. Guidelines taskforces, consisting of HCT specialists, other pediatric oncologists, radiation oncologists, organ-specific subspecialists, nurses, social workers, other healthcare professionals, and patient advocates have systematically reviewed the literature with regards to late effects after childhood cancer and HCT since 2002, with the most recent review completed in 2013. For the most recent review cycle, over 800 articles from the medical literature relevant to childhood cancer and HCT survivorship were reviewed, including 586 original research articles. Provided here-in is an organ system-based overview that emphasizes the most relevant COG recommendations (with accompanying evidence grade) for the long-term follow-up care of childhood HCT survivors (regardless of current age) based on a rigorous review of the available evidence. These recommendations cover both autologous and allogeneic HCT survivors, those transplanted for non-malignant diseases, and those with a history of chronic GVHD.

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“…1 Twelve of the 13 patients described above had radiation in a field that included their esophagus. 4 However, none of the children reported in our article had prior radiotherapy proving that other causes are important. Isolated cases have been reported of postchemotherapy esophageal stricture in the absence of radiotherapy, all in patients with acute leukemia.…”

Section: Discussionmentioning

confidence: 60%

“…1 A later review of all pediatric oncology patients treated at Memorial Sloan Kettering over a 23-year period identified 13 patients who developed esophageal strictures after treatment, 5 of whom were included in the earlier review. 4 The etiology of esophageal stricture in pediatric oncology is multifactorial. Radiation therapy seems to be most important.…”

Section: Discussionmentioning

confidence: 99%

Esophageal Strictures During Treatment for Acute Lymphoblastic Leukemia

Kelly¹,

Storey²,

Sullivan³

et al. 2010

Journal of Pediatric Hematology/Oncology

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Esophageal stricture is a rare complication of paediatric cancer treatment that usually occurs after esophageal exposure to radiotherapy. We describe 4 cases of esophageal stricture during chemotherapy for acute lymphoblastic leukemia. All patients presented with refractory vomiting and were diagnosed with radiologic contrast studies. None of the patients had received radiotherapy. Esophageal candidiasis was seen in 2 patients but the remaining 2 patients had earlier systemic candidiasis. High-dose dexamethasone may predispose these children to both esophageal candidiasis and peptic esophagitis. The etiology of esophageal strictures during treatment for acute leukemia is likely to be multifactorial but systemic candidiasis may play a significant role.

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The management of treatment-related esophageal complications in children and adolescents with cancer

Cited by 30 publications

References 16 publications

Determining mucosal barrier injury to the oesophagus using CT scan

Determining mucosal barrier injury to the oesophagus using CT scan

Late Effects Surveillance Recommendations among Survivors of Childhood Hematopoietic Cell Transplantation: A Children's Oncology Group Report

Esophageal Strictures During Treatment for Acute Lymphoblastic Leukemia

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