The manifestation of cocaine-induced midline destructive lesion in bone tissue and its identification in human skeletal remains

Rubin, Katie M.

doi:10.1016/j.forsciint.2013.04.034

Cited by 20 publications

(29 citation statements)

References 96 publications

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“…Nasal and palatal involvement can become extremely severe: snorting causes lytic destruction of the vomer, extending to the perpendicular plate of the ethmoid bone, resulting in nasal septum perforation, destruction of the lateral nasal walls, maxillary and ethmoid sinuses inflammation and typical deformation of nasal pyramid bones, called saddle nose deformity 6 7. In more advanced lesions, inferior, middle and superior nasal conchae are involved, with progressive resorption, allowing to an infection spread to the sphenoid sinus and the orbit 8. The progressive infection and resorption of facial tissues is commonly called cocaine-induced midline destructive lesion, an acquired life-threatening condition 9…”

Section: Global Health Problem Analysismentioning

confidence: 99%

Snorting the clivus away: an extreme case of cocaine-induced midline destructive lesion

et al. 2016

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Cocaine is a drug with relevant socioeconomic and clinical implications, which is usually recreationally used for its stimulant effects. It is widely known that the habit of snorting cocaine is associated with a peculiar type of drug-induced chronic rhinitis, which leads to inflammation of the sinonasal mucosa, slowly progressing to a destruction of nasal, palatal and pharyngeal tissues. These characteristic lesions due to cocaine abuse are commonly called cocaine-induced midline destructive lesions (CIMDL). Diagnosis is not always straightforward, since various conditions, mainly vasculitis, might mimic this acquired condition. The extent of pharyngeal involvement varies, although often a prolonged abuse can trigger a progressive destruction of oral and nasal tissues, with development of infections and recurrent inflammation. Our article focuses on cocaine as a world health problem with important ear, nose and throat implications and discusses the difficulties in diagnosing and treating CIMDL, through a case report.

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Section: Global Health Problem Analysismentioning

confidence: 99%

Snorting the clivus away: an extreme case of cocaine-induced midline destructive lesion

et al. 2016

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“…Chronic use of recreational or illicit drugs such as cocaine, amphetamine and methamphetamine are established independent risk factors for osteonecrosis, termed Recreational drug induced osteonecrosis (RDIO) 29-32 . It is more common in the maxilla 29 .…”

Section: Types Of Osteonecrosismentioning

confidence: 99%

“…Although several recreational drugs have been implicated, cocaine in particular induces vascular constriction that results in local ischemia of the adjacent soft and hard tissues 33 . It has been proposed that the combined effect of chemical irritation from additives to the recreational drug, trauma and superimposed microbial infection accentuate the necrotic process that leads to bone destruction 32 . Therefore, excessive bone destruction caused by nasal inhalation or snorting of a recreational drug like cocaine initially starts as ulceration of mucosal tissue that progressively leads to osteocartilaginous necrosis.…”

Section: Types Of Osteonecrosismentioning

confidence: 99%

“…If uncontrolled, the nasal septum and palate become perforated consequently leading to oro-nasal and oro-antral fistulations 30, 34 . Specifically, cocaine-induced midline destructive lesion (CIMDL) has been used to describe extensive destruction caused by cocaine addiction to the oro-nasal structures including the hard palate 32 . This extensive osteonecrosis of the bony structures is one of the hallmarks used to identify CIMDL in the assessment of human skeletal remains by medical examiners and forensic scientists.…”

Section: Types Of Osteonecrosismentioning

confidence: 99%

“…The additional use of the combinations of fluorodeoxyglucose/positron emission tomography (FDG/PET) and single photon emission computed tomography (SPECT)/CT combination have also been shown to improve diagnostic accuracy because they provide functional and anatomic co-registration of the extent of the osteonecrosis 32, 39-41 . Magnetic resonance imaging (MRI) can display osteonecrosis as decreased marrow signal intensity on T1-weighted images and increased signal intensity on T2-weighted images.…”

Section: Radiological Features Of Osteonecrosismentioning

confidence: 99%

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Chemical and Radiation-Associated Jaw Lesions

Omolehinwa

Akintoye

2016

Dental Clinics of North America

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Synopsis Osteonecrosis of the jaw, at one time considered to be infrequent has now become a major public health concern not only in the United States, but throughout the world. The wide-spread use of radiotherapy for head and neck cancer as well as bone antiresorptives and antiangiogenic agents have increased the incidence of osteonecrosis. While the exact pathophysiological process of osteonecrosis is yet to be clearly defined, there has been a much higher incidence of medication-related osteonecrosis of the jaw relative to the other types of osteonecrosis. The traditional osteoradionecrosis still occurs despite better treatment planning and shielding to minimize collateral damage to bone. There are other related necrotic lesions secondary to usage of recreation drugs and the use of steroids. This chapter will give comprehensive information about these different types of bone necrosis; provide the readers with radiographic diagnostic criteria and updates on current theories on pathophysiology of osteonecrosis.

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Computer‐assisted planning with 3D printing for mandibular reconstruction caused by a mandibular fracture with secondary osteomyelitis: A Case Report

Hale

Romero-Araya

Herrera

et al. 2021

Clinical Case Reports

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Mandibular reconstruction after trauma or pathology is one of the cornerstones of oral and maxillofacial surgery. 1 This reconstruction is needed in cases with a large amount of bone loss, comminute fractures, severe traumas, and infections leading to multiple bone sequestrations. 2 In the case of infections of the bone, different risk factors may enhance the speed in which the bone is lost, such as age, sex, poor oral hygiene, comorbidities (diabetes, hyperlipemia, autoimmune diseases), and drug abuse (cocaine, cannabinoid, tobacco smoking, hepatic cirrhosis due alcoholism). [3][4][5][6][7][8] The four basic principles of successful reconstruction are (a) establish an ideal orthognathic relationship; (b) a flush bone to graft/flap contact; (c) stable bony fixation; and (d) adequate, well-vascularized soft tissue coverage. 1 To achieve the previously established principles, the maxillofacial literature describes different surgical treatment

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The manifestation of cocaine-induced midline destructive lesion in bone tissue and its identification in human skeletal remains

Cited by 20 publications

References 96 publications

Snorting the clivus away: an extreme case of cocaine-induced midline destructive lesion

Snorting the clivus away: an extreme case of cocaine-induced midline destructive lesion

Chemical and Radiation-Associated Jaw Lesions

Computer‐assisted planning with 3D printing for mandibular reconstruction caused by a mandibular fracture with secondary osteomyelitis: A Case Report

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