The Manifestation of the Urinogenital Papillae of the Medaka (Oryzias Latipes) by Sex-Hormones

Yamamoto, Taiki; Suzuki, Hajime

doi:10.1111/j.1440-169x.1955.tb00047.x

Cited by 29 publications

(18 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Secondary sexual characteristics, such as male nuptial colouration or UGP development, are known to be hormonally controlled in fishes (e.g. Borg & Mayer, 1995;Yamamoto & Suzuki, 1955). In this study, male nuptial colouration was delayed and inhibited by exposure to OP, but UGP length was not affected.…”

Section: Discussionmentioning

confidence: 44%

Effects of prolonged exposure to 4-tert-octylphenol on toxicity and indices of oestrogenic exposure in the sand goby (Pomatoschistus minutus, Pallas)

Robinson

Brown

Craft

et al. 2004

Marine Environmental Research

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 44%

Effects of prolonged exposure to 4-tert-octylphenol on toxicity and indices of oestrogenic exposure in the sand goby (Pomatoschistus minutus, Pallas)

Robinson

Brown

Craft

et al. 2004

Marine Environmental Research

View full text Add to dashboard Cite

“…The presence of a conspicuous UGP is a strong indication of sexual maturity in medaka females, and ovaries of such females harbor late-and post-vitellogenic follicles [Yamamoto, 1953]. UGP development is sensitive to the circulating levels of sex steroids [Yamamoto and Suzuki, 1955;Brionet al, 2004] and incidentally, the scl mutants, incapable of producing sex hormones because of a loss-of-function mutation in the P450c17 gene, were not found to display both male-and female-specific secondary sexual characteristics including UGP [Sato et al, 2008]. Though estrogen was said to have a dominant role on development of UGP [Yamamoto and Suzuki, 1955], the roles of other hormones in this regard were not completely ruled out [Sato et al, 2008].…”

Section: Discussionmentioning

confidence: 99%

“…UGP development is sensitive to the circulating levels of sex steroids [Yamamoto and Suzuki, 1955;Brionet al, 2004] and incidentally, the scl mutants, incapable of producing sex hormones because of a loss-of-function mutation in the P450c17 gene, were not found to display both male-and female-specific secondary sexual characteristics including UGP [Sato et al, 2008]. Though estrogen was said to have a dominant role on development of UGP [Yamamoto and Suzuki, 1955], the roles of other hormones in this regard were not completely ruled out [Sato et al, 2008]. Hence, observation of a prominent UGP and presence of advanced stage follicles in females exposed to DEN in comparison to the control females suggested it to have a potent role on UGP development and follicular growth.…”

Section: Discussionmentioning

confidence: 99%

Effects of N-Nitrosodiethylamine, a Potent Carcinogen, on Sexual Development, Gametogenesis, and Oocyte Maturation

Victor²,

Paul³

et al. 2017

Sex Dev

View full text Add to dashboard Cite

N-Nitrosodiethylamine (DEN), a well-known hepatocarcinogen, is found in certain food products as such or as a metabolic byproduct. This study investigated the effects of DEN on sexual development, gametogenesis, and oocyte maturation in Japanese medaka (Oryzias latipes). DEN reduced the germ cell number dose-dependently during early stages of sexual differentiation in XX larvae, resulting in underdeveloped ovaries in adulthood at low doses. This effect was sex-specific as no such changes were seen in XY larvae. Furthermore, XX and XY larvae that were exposed at a low dose during early life showed a significant reduction in body weight in adulthood. Gonads in sexually immature adult medaka males and females exposed to DEN were in advanced stages in comparison to that of the controls. Gonado-somatic indices were significantly high in treated males and females. DEN induced oocyte maturation in vitro, which was inhibited by cordycepin, demonstrating that it stimulated oocyte maturation through polyadenylation of cyclin B mRNA as in the case of the endogenous maturation-inducing hormone. Altogether, our results have proven that DEN could disrupt or mimic the signaling pathways involved in germ cell development, proliferation, and maturation.

show abstract

“…Only a few studies have focused specifically on effects on the UGP after EDC exposure. These include exposure studies done on Danio rerio (zebrafish) (Brion et al, 2004); Etheostoma caeruleum (rainbow darter) (Elias et al, 2007); Lythrypnus dalli (bluebanded goby) (Kirby et al, 2003); Oryzias latipes (Japanese medaka) (Yamamato and Suzuki, 1955;Parrott et al, 2003), and exposed or wild collected specimens of Pomatoschistus minutus. (sand goby) (Matthiessen et al, 2002;Kirby et al, 2003;Robinson et al, 2003;Robinson et al, 2004;Rodrigues et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

The use of the urogenital papillae of male feral African sharptooth catfish (Clarias gariepinus) as indicator of exposure to estrogenic chemicals in two polluted dams in an urban nature reserve, Gauteng, South Africa

Kruger

Barnhoorn

Vuren

et al. 2013

Ecotoxicology and Environmental Safety

View full text Add to dashboard Cite

The use of the urogenital papillae of male feral African sharptooth catfish (Clarias gariepinus) as indicator of exposure to estrogenic chemicals in two polluted dams in an urban nature reserve, Gauteng, South Africa AbstractThe African sharptooth catfish (Clarias gariepinus) is indigenous to South Africa where it is commonly found in calm waters such as lakes, streams, rivers, swamps and floodplains. The males of this gonochoristic species can be readily distinguished from females via a distinct elongated urogenital papilla with a pointed tip, located just behind the anus. This structure is an androgen controlled secondary sexual characteristic and could potentially be affected by chemicals displaying endocrine disrupting properties during development. Results of previous studies on effects on papillae of different fish species indicated that these structures could be useful as bio-indicators of exposure due to alterations in the structures. This study investigated the occurrence of abnormal morphology in urogenital papillae compared to the macroscopic and microscopic structure of the gonads of presumed male or intersex catfish sampled from the Rietvlei and Marais dams in an urban nature reserve, due to exposure to endocrine disrupting chemicals (EDCs). Macroscopic observation of the UGP, gonad examination after laparotomy and histology were done. Gonadosomatic index (GSI) and Urogenital papilla length index (UGPLI) were determined for all fish collected. Mesenteric fat analyzed for selected alkylphenols and organochlorines showed high levels of especially nonylphenol indicating long term exposure to these chemicals due to bio-accumulation. The GSI indicated that fish with intersex gonads were probably feminized males. It was concluded that use of the UGP alone, without macroscopic and microscopic analyses of the gonads, could not effectively indicate exposure to EDCs.

show abstract

The Manifestation of the Urinogenital Papillae of the Medaka (Oryzias Latipes) by Sex-Hormones

Cited by 29 publications

References 17 publications

Effects of prolonged exposure to 4-tert-octylphenol on toxicity and indices of oestrogenic exposure in the sand goby (Pomatoschistus minutus, Pallas)

Effects of prolonged exposure to 4-tert-octylphenol on toxicity and indices of oestrogenic exposure in the sand goby (Pomatoschistus minutus, Pallas)

Effects of N-Nitrosodiethylamine, a Potent Carcinogen, on Sexual Development, Gametogenesis, and Oocyte Maturation

The use of the urogenital papillae of male feral African sharptooth catfish (Clarias gariepinus) as indicator of exposure to estrogenic chemicals in two polluted dams in an urban nature reserve, Gauteng, South Africa

Contact Info

Product

Resources

About