The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production

The mannose receptor

“…Additional support for a role of MR in promoting Th2 polarization has been obtained during the investigation of early events during infection with S. mansoni cercariae [72]. MR binds excretory/secretory material released during transformation of cercariae into schistosomula and contributes to early Th2 polarization in response to Schistosoma infection.…”

Virulence factors of schistosomes

“…In vitro, macrophages are slower to take up the secretions than dendritic cells but produce more (suppressive) IL-10 [24]. Ligands for the mannose receptor (CD206), presumably glycans, are abundant in the secretions [25]. In this context it is notable that schistosomes, unlike the mammalian hosts, do not terminate their sugar chains with sialic acid, lacking the necessary transferase enzyme.…”

Mannose receptor mediated phagocytosis of bacteria in macrophages of blunt snout bream (Megalobrama amblycephala) in a Ca2+-dependent manner

“…MR is able to bind a wide range of pathogens, such as bacteria and viruses, by the recognition of mannose residues on the surfaces of these microorganisms [5,22]. It has been shown that MR contains multiple C-type lectin domains which display Ca 2þ -dependent binding to terminal mannose residues [9].…”

“…MR is able to bind and mediate the phagocytosis of a wide range of microorganisms, including viruses, bacteria, yeasts and parasites, such as HIV [2], Mycobacterium tuberculosis [3], Leishmania donovani [4], Schistosoma mansoni [5], Pneumocystis carinii [6] and Saccharomyces cerevisiae [7]. MR is a typical type I transmembrane receptor, it contains an N-terminal cysteine-rich domain (CR), a single fibronectin type II domain (FNII), eight tandemly arranged C-type lectin-like domains (CTLDs), a single transmembrane domain and a short C-terminal cytoplasmic domain [8e10].…”

“…MR is a typical type I transmembrane receptor, it contains an N-terminal cysteine-rich domain (CR), a single fibronectin type II domain (FNII), eight tandemly arranged C-type lectin-like domains (CTLDs), a single transmembrane domain and a short C-terminal cytoplasmic domain [8e10]. MR CTLDs display Ca 2þ -dependent binding to the terminal mannose, fucose and Nacetylglucosamine residues that are frequently found on the pathogen surfaces and mediate diverse immune responses [5]. It has been demonstrated that Ca 2þ was essential to the activity of MR in the mammalian macrophages [11].…”