The 3D printing parameters are known to have a significant impact on manufactured parts, and the layered morphology of these parts makes mechanical design analysis for engineering applications difficult. In this work, the tensile strengths and microhardness of 3D printed polylactic acid (PLA) specimens with different orientations and numbers of individual layers of mesh material (polyvinyl chloride – PVC) were investigated as a laminate composite. Composite specimens were obtained using 3D printing via fused deposition modelling (FDM). Moreover, the influence of printing parameters (i.e. infill density and layer height) and the number and orientation of reinforced meshes on the mechanical response was investigated. Fracture strength of PLA/PVC laminate composites ranges from 31.30 MPa (3 PVC mesh layers; mesh height position: 25 %│50 %│75 %; infill density: 60 %; PVC mesh orientation: 90°│45°│90°; layer height: 0.2 mm) to 18.62 MPa (without PVC mesh; infill density: 30 %; layer height: 0.1 mm) demonstrating a significant impact of the number of the PVC mesh layers, infill density of PLA and layer height on the final mechanical parameters of printing PLA/PVC elements. The surface hardness at the micro load level showed that the number of reinforcement layers affects the microhardness value, as well as material filling and mesh orientation. The specimen with the following parameters gave the best results: layer height: 0.2 mm; 3 PVC mesh layers; infill density: 60 %; PVC mesh orientation: 90°│45°│90°. The average hardness values for one layer and three layers of mesh were in accordance with tensile test results.