The many faces of DNA polymerases: Strategies for mutagenesis and for mutational avoidance

8-(Hydroxymethyl)-3,N4-etheno-C, a Potential Carcinogenic Glycidaldehyde Product, Miscodes In Vitro Using Mammalian DNA Polymerases

“…A current view holds that when highly processive, semiconservative DNA replication is blocked by a DNA lesion, the replicative machinery is displaced from the replication fork and replaced by these lesion-specific DNA polymerases (for review, see (12).…”

“…Our approach in understanding the mechanism is to examine how this adduct may affect in vitro replication processes using mammalian polymerases, which are a key factor in maintaining genomic integrity. There are a number of human DNA-directed polymerases which have been identified as having lesion-bypassing capacity in addition to their various roles in cellular functions (for reviews see refs (11,12). Polymerase α (pol α) exhibits high fidelity, and is a moderately processive enzyme (13), functioning in both DNA replication and repair.…”

Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins

“…(5) In subsequent years, different types of DNA polymerases were discovered in all organisms, including an amazing sixteen in mammalian cells. (6) Their many fascinating features have been reviewed elsewhere. (7) Replicative DNA polymerases work in conjunction with many accessory activities, forming a ''replisome'' complex at the replication fork (reviewed in 8).…”

.BETA.-Sitosteryl (6'-O-linoleoyl)-glucoside of Soybean (Glycine max L.) Crude Extract Inhibits Y-Family DNA Polymerases

“…In XPV patients, alternative error-prone pols, such as the B-family pol ζ, are thought to be involved in the errors that result in the cancer predisposition of these patients. Other members of the Y-family in humans pols ι, κ, and REV1 are thought to be involved in bypassing different lesions 7,31 . Therefore, the inhibitors of Y-family pols may be useful as anticancer drugs for clinical radiation therapy.…”