2022
DOI: 10.3389/fmolb.2022.873777
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The Many Faces of G Protein-Coupled Receptor 143, an Atypical Intracellular Receptor

Abstract: GPCRs transform extracellular stimuli into a physiological response by activating an intracellular signaling cascade initiated via binding to G proteins. Orphan G protein-coupled receptors (GPCRs) hold the potential to pave the way for development of new, innovative therapeutic strategies. In this review we will introduce G protein-coupled receptor 143 (GPR143), an enigmatic receptor in terms of classification within the GPCR superfamily and localization. GPR143 has not been assigned to any of the GPCR familie… Show more

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Cited by 8 publications
(4 citation statements)
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References 219 publications
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“…First, it is possible that the deletion of exons 2 to 8 of GPR143 , presumably resulting in a complete loss of expression of the protein in males, directly contributed to the patient’s psychopathology. The protein encoded by GPR143 is widely distributed in the central and peripheral nervous system and may function as an L-DOPA receptor in vivo 13,14. L-DOPA is a precursor of dopamine synthesis and may also itself have a neurotransmitter function.…”
Section: Discussionmentioning
confidence: 99%
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“…First, it is possible that the deletion of exons 2 to 8 of GPR143 , presumably resulting in a complete loss of expression of the protein in males, directly contributed to the patient’s psychopathology. The protein encoded by GPR143 is widely distributed in the central and peripheral nervous system and may function as an L-DOPA receptor in vivo 13,14. L-DOPA is a precursor of dopamine synthesis and may also itself have a neurotransmitter function.…”
Section: Discussionmentioning
confidence: 99%
“…The protein encoded by GPR143 is widely distributed in the central and peripheral nervous system and may function as an L-DOPA receptor in vivo. 13,14 L-DOPA is a precursor of dopamine synthesis and may also itself have a neurotransmitter function. GPR143 immunoreactive cells have been detected in the hippocampus, cerebral cortex, striatum, substantia nigra, hypothalamic median eminence, suprachiasmatic nucleus, caudal ventrolateral medulla, and olfactory bulb, 13 reflecting regions involved in multiple circuits of neuropsychiatric interest.…”
Section: Discussionmentioning
confidence: 99%
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“…GPR143/OA1 is a melanosome G-protein-coupled receptor, whose mutations have been associated with type I ocular albinism [62]. GPR143 protein sustains MITF expression, and hence PMEL expression, therefore contributing to correct melanosome maturation [63].…”
Section: Validation Of Demirs and Demrnas Identified By Bioinformatic...mentioning
confidence: 99%