The Many Faces of Gastrin …

Dj, Byrnes; Lazarus, L.; Jd, Young

doi:10.1111/imj.1970.19.4.380

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…This group also reports serum gastrin levels to be grossly elevated in duodenal ulcer (Byrnes et al, 1970a) and the reasons for this controversy have already been discussed (Hansky, Korman, and Soveny, 1970;Byrnes, Lazarus, and Young, 1970b;Korman, Soveny, and Hansky, 1971b). Dragstedt (1969) has postulated increased vagal drive to account for the increased parietal cell mass in duodenal ulcer.…”

Section: Resultsmentioning

confidence: 99%

Serum gastrin in duodenal ulcer: Part I Basal levels and effect of food and atropine

Korman¹,

Soveny²,

Hansky³

1971

Gut

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Section: Resultsmentioning

confidence: 99%

Serum gastrin in duodenal ulcer: Part I Basal levels and effect of food and atropine

Korman¹,

Soveny²,

Hansky³

1971

Gut

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“…The time differences of these responses may be explained on the basis that the groups are measuring different components of gastrin (Byrnes, Lazarus, and Young, 1970b). The present assay and that of McGuigan and Trudeau (1970), based on antibodies to human gastrin I, measure gastrin I, gastrin II, and probably 'big' gastrin , and these may be the forms of 'gastrin' released by local stimulation.…”

Section: Protein Mealmentioning

confidence: 81%

Effect of food on serum gastrin evaluated by radioimmunoassay

Korman¹,

Soveny²,

Hansky³

1971

Gut

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SUMMARY The effect of food on serum gastrin in normal man has been evaluated by radioimmunoassay. Protein and amino acids produced up to a five-fold increase in serum gastrin levels, followed in potency by alcohol, fat, and glucose. Distilled water did not stimulate the release of gastrin. An injection of atropine sulphate (0.6 mg) augmented the response to all good stimuli but in itself did not affect serum gastrin levels in the basal state.In animals the release of gastrin in response to feeding involves both vagal impulses (Uvnas, 1942) and the activation of a local mechanism in the antrum (Woodward, Lyon, Landor, and Dragstedt, 1954;Baugh, Bravo, Barcena, and Dragstedt, 1956;Elwin and Nilsson, 1963).Sensitive radioimmunoassay now permits the direct measurement of gastrin levels in serum, and rises in immunoreactive gastrin have been reported following both feeding (Hansky and Cain, 1969;McGuigan and Trudeau, 1970) and insulin hypoglycaemia (Korman, Soveny, and Hansky, 1971).This study examines the effect of standard meals and individual food constituents on serum immunoreactive gastrin with and without prior atropinization. Material and MethodsNormal healthy volunteers were investigated after an overnight fast. These comprised 20 males and three females between the ages of 20 and 30 years. Subjects were investigated in groups of at least four, and informed consent was obtained from each subject. A 19-gauge needle was inserted into a forearm vein and patency ensured by frequent flushing with a solution of heparin, 1,000 units in 20 ml of 09% sodium chloride. This solution has been shown not to affect serum gastrin levels.Three groups had a meal which was high in either protein, carbohydrate, or fat, and blood was drawn for gastrin estimation at - 90, -60, -30, 0, 15, 30, 45, 60, 75, 90, 105, and 120 minutes. The test was

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Gastrin

McGuigan¹

1975

Vitamins &Amp; Hormones

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The Many Faces of Gastrin …

Cited by 3 publications

References 7 publications

Serum gastrin in duodenal ulcer: Part I Basal levels and effect of food and atropine

Serum gastrin in duodenal ulcer: Part I Basal levels and effect of food and atropine

Effect of food on serum gastrin evaluated by radioimmunoassay

Gastrin

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